{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:42:55Z","timestamp":1753886575650,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Stein Erik Hagens Foundation for Clinical Heart Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Fractalkine is a chemokine associated with atherosclerosis. Increased serum levels have been reported in unstable coronary artery disease (CAD) and to predict mortality in heart failure. Mediterranean\u2010like diet and omega\u20103 fatty acids (n3\u2010PUFA) have documented cardioprotective and anti\u2010inflammatory effects. We have investigated the effect of Mediterranean\u2010like dietary counseling and n\u20103 PUFA on serum fractalkine in an elderly population and its ability to predict cardiovascular disease (CVD). <jats:italic>Materials and Methods<\/jats:italic>. 563 men (age 64\u201375\u2009yrs) at high risk of CAD were randomized into a 2\u2009\u00d7\u20092 factorial designed trial for 3\u2010year dietary counseling and\/or n\u20103 PUFA supplementation (2.4\u2009g\/d). Circulating levels of fractalkine were measured at baseline and at end of study. Clinical events were recorded after 3 years. <jats:italic>Results<\/jats:italic>. Fractalkine levels were significantly reduced in all groups from baseline to 3 years (<jats:italic>P<\/jats:italic> &lt; 0.001, all), but without between\u2010group differences in changes. Fractalkine levels at baseline were not predictive for CVD events (<jats:italic>n<\/jats:italic> = 68) or total mortality. Lower fractalkine levels were observed in smokers (<jats:italic>P<\/jats:italic> = 0.019). <jats:italic>Conclusions<\/jats:italic>. Reduced levels of fractalkine from baseline to 3 years were observed, however, without any influence of Mediterranean\u2010like diet or n\u20103 PUFA supplementation. Fractalkine levels at baseline were not predictive for later CVD events.<\/jats:p>","DOI":"10.1155\/2015\/373070","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T21:01:31Z","timestamp":1423170091000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects on Serum Fractalkine by Diet and Omega\u20103 Fatty  Acid Intervention: Relation to Clinical Outcome"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2925-0823","authenticated-orcid":false,"given":"Kristian","family":"Laake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingebj\u00f8rg","family":"Seljeflot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten 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