{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:18:38Z","timestamp":1784776718329,"version":"3.55.0"},"reference-count":83,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Vicerrector\u00eda de Investigaci\u00f3n y Estudios de Posgrado","award":["NAT\/2014"],"award-info":[{"award-number":["NAT\/2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Prophylactic subacute administration of zinc decreases lipoperoxidation and cell death following a transient cerebral hypoxia-ischemia, thus suggesting neuroprotective and preconditioning effects. Chemokines and growth factors are also involved in the neuroprotective effect in hypoxia-ischemia. We explored whether zinc prevents the cerebral cortex-hippocampus injury through regulation of CCL2, CCR2, FGF2, and IGF-1 expression following a 10\u2009min of common carotid artery occlusion (CCAO). Male rats were grouped as follows: (1) Zn96h, rats injected with ZnCl<jats:sub>2<\/jats:sub>(one dose every 24\u2009h during four days); (2) Zn96h + CCAO, rats treated with ZnCl<jats:sub>2<\/jats:sub>before CCAO; (3) CCAO, rats with CCAO only; (4) Sham group, rats with mock CCAO; and (5) untreated rats. The cerebral cortex-hippocampus was dissected at different times before and after CCAO. CCL2\/CCR2, FGF2, and IGF-1 expression was assessed by RT-PCR and ELISA. Learning in Morris Water Maze was achieved by daily training during 5 days. Long-term memory was evaluated on day 7 after learning. Subacute administration of zinc increased expression of CCL2, CCR2, FGF2, and IGF-1 in the early and late phases of postreperfusion and prevented the CCAO-induced memory loss in the rat. These results might be explained by the induction of neural plasticity because of the expression of CCL2 and growth factors.<\/jats:p>","DOI":"10.1155\/2015\/375391","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T17:02:25Z","timestamp":1439917345000},"page":"1-15","source":"Crossref","is-referenced-by-count":16,"title":["Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia"],"prefix":"10.1155","volume":"2015","author":[{"given":"Victor Manuel","family":"Blanco-Alvarez","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, BUAP, 14 Sur y Avenida San Claudio, 72570 Puebla, PUE, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Soto-Rodriguez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, BUAP, 14 Sur y Avenida San Claudio, 72570 Puebla, PUE, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Gonzalez-Barrios","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica, Hospital Regional 1\u00b0 de Octubre, ISSSTE, Avenida Instituto Polit\u00e9cnico Nacional No. 1669, 07760 M\u00e9xico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Martinez-Fong","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Biof\u00edsica y Neurociencias, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Apartado Postal 14-740, 07000 M\u00e9xico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0377-0943","authenticated-orcid":true,"given":"Eduardo","family":"Brambila","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, BUAP, 14 Sur y Avenida San Claudio, 72570 Puebla, PUE, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricela","family":"Torres-Soto","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, BUAP, 14 Sur y Avenida San Claudio, 72570 Puebla, PUE, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Karina","family":"Aguilar-Peralta","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, BUAP, 14 Sur y Avenida San Claudio, 72570 Puebla, PUE, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gonzalez-Vazquez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, BUAP, 14 Sur y Avenida San Claudio, 72570 Puebla, PUE, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantino","family":"Tom\u00e1s-Sanchez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, BUAP, 14 Sur y Avenida San Claudio, 72570 Puebla, PUE, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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