{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:02:30Z","timestamp":1775307750341,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI044856 (GMR)"],"award-info":[{"award-number":["AI044856 (GMR)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Mycobacterium tuberculosis<\/jats:italic>the causative agent of tuberculosis affects millions of people worldwide. New tools for treatment and prevention of tuberculosis are urgently needed. We previously showed that a ferritin (<jats:italic>bfrB<\/jats:italic>) mutant of<jats:italic>M. tuberculosis<\/jats:italic>has altered iron homeostasis and increased sensitivity to antibiotics and to microbicidal effectors produced by activated macrophages. Most importantly,<jats:italic>M. tuberculosis<\/jats:italic>lacking BfrB is strongly attenuated in mice, especially, during the chronic phase of infection. In this study, we examined whether immunization with a<jats:italic>bfrB<\/jats:italic>mutant could confer protection against subsequent infection with virulent<jats:italic>M. tuberculosis<\/jats:italic>in a mouse model. The results show that the protection elicited by immunization with the<jats:italic>bfrB<\/jats:italic>mutant is comparable to BCG vaccination with respect to reduction of bacterial burden. However, significant distinctions in the disease pathology and host genome-wide lung transcriptome suggest improved containment of Mtb infection in animals vaccinated with the<jats:italic>bfrB<\/jats:italic>mutant, compared to BCG. We found that downmodulation of inflammatory response and enhanced fibrosis, compared to BCG vaccination, is associated with the protective response elicited by the<jats:italic>bfrB<\/jats:italic>mutant.<\/jats:p>","DOI":"10.1155\/2015\/385402","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T02:28:15Z","timestamp":1438655295000},"page":"1-12","source":"Crossref","is-referenced-by-count":15,"title":["Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent<i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2021-8632","authenticated-orcid":true,"given":"Selvakumar","family":"Subbian","sequence":"first","affiliation":[{"name":"Laboratory of Mycobacterial Immunity and Pathogenesis, Rutgers, The State University of New Jersey, 225 Warren Street, Newark, NJ 07103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-7415","authenticated-orcid":true,"given":"Ruchi","family":"Pandey","sequence":"additional","affiliation":[{"name":"Public Health Research Institute at Rutgers Biomedical and Health Sciences, Rutgers, The State University of New Jersey, 225 Warren Street, Newark, NJ 07103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Soteropoulos","sequence":"additional","affiliation":[{"name":"Public Health Research Institute at Rutgers Biomedical and Health Sciences, Rutgers, The State University of New Jersey, 225 Warren Street, Newark, NJ 07103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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