{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:10:34Z","timestamp":1785798634221,"version":"3.56.0"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Federico G\u00f3mez Children\u2019s Hospital","award":["HIM\/018\/2013"],"award-info":[{"award-number":["HIM\/018\/2013"]}]},{"name":"Federico G\u00f3mez Children\u2019s Hospital","award":["CB-2010-01-152695"],"award-info":[{"award-number":["CB-2010-01-152695"]}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["HIM\/018\/2013"],"award-info":[{"award-number":["HIM\/018\/2013"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CB-2010-01-152695"],"award-info":[{"award-number":["CB-2010-01-152695"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>B-cell acute lymphoblastic leukemia (B-ALL) is a serious public health problem in the pediatric population worldwide, contributing to 85% of deaths from childhood cancers. Understanding the biology of the disease is crucial for its clinical management and the development of therapeutic strategies. In line with that observed in other malignancies, chronic inflammation may contribute to a tumor microenvironment resulting in the damage of normal processes, concomitant to development and maintenance of neoplastic cells. We report here that hematopoietic cells from bone marrow B-ALL have the ability to produce proinflammatory and growth factors, including TNF<jats:italic>\u03b1<\/jats:italic>, IL-1<jats:italic>\u03b2<\/jats:italic>, IL-12, and GM-CSF that stimulate proliferation and differentiation of normal stem and progenitor cells. Our findings suggest an apparently distinct CD13<jats:sup>+<\/jats:sup>CD33<jats:sup>+<\/jats:sup>population of leukemic cells contributing to a proinflammatory microenvironment that may be detrimental to long-term normal hematopoiesis within B-ALL bone marrow.<\/jats:p>","DOI":"10.1155\/2015\/386165","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T19:26:57Z","timestamp":1431977217000},"page":"1-14","source":"Crossref","is-referenced-by-count":38,"title":["Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates"],"prefix":"10.1155","volume":"2015","author":[{"given":"Armando","family":"Vilchis-Ordo\u00f1ez","sequence":"first","affiliation":[{"name":"\u201cFederico G\u00f3mez\u201d Children\u2019s Hospital, 06720 Mexico City, DF, Mexico"},{"name":"Oncology Research Unit, Oncology Hospital, Mexican Institute for Social Security, Avenida Cuauhtemoc 330, Colonia Doctores, 06720 Mexico City, DF, Mexico"},{"name":"Clinical Biochemistry Program, National Autonomous University of Mexico, 04510 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Contreras-Quiroz","sequence":"additional","affiliation":[{"name":"Oncology Research Unit, Oncology Hospital, Mexican Institute for Social Security, Avenida Cuauhtemoc 330, Colonia Doctores, 06720 Mexico City, DF, Mexico"},{"name":"Molecular Biomedicine Department, CINVESTAV, 07360 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-8031","authenticated-orcid":true,"given":"Eduardo","family":"Vadillo","sequence":"additional","affiliation":[{"name":"Oncology Research Unit, Oncology Hospital, Mexican Institute for Social Security, Avenida Cuauhtemoc 330, Colonia Doctores, 06720 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Dorantes-Acosta","sequence":"additional","affiliation":[{"name":"\u201cFederico G\u00f3mez\u201d Children\u2019s Hospital, 06720 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Reyes-L\u00f3pez","sequence":"additional","affiliation":[{"name":"\u201cFederico G\u00f3mez\u201d Children\u2019s Hospital, 06720 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Martin","family":"Quintela-Nu\u00f1ez del Prado","sequence":"additional","affiliation":[{"name":"UMAE \u201cDr. Victorio de la Fuente Narva\u00e9z\u201d, Mexican Institute for Social Security, 07760 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Venegas-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"UMAE \u201cDr. Victorio de la Fuente Narva\u00e9z\u201d, Mexican Institute for Social Security, 07760 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Mayani","sequence":"additional","affiliation":[{"name":"Oncology Research Unit, Oncology Hospital, Mexican Institute for Social Security, Avenida Cuauhtemoc 330, Colonia Doctores, 06720 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vianney","family":"Ortiz-Navarrete","sequence":"additional","affiliation":[{"name":"Molecular Biomedicine Department, CINVESTAV, 07360 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briceida","family":"L\u00f3pez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"\u201cFederico G\u00f3mez\u201d Children\u2019s Hospital, 06720 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana","family":"Pelayo","sequence":"additional","affiliation":[{"name":"Oncology Research Unit, Oncology Hospital, Mexican Institute for Social Security, Avenida Cuauhtemoc 330, Colonia Doctores, 06720 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2011.12.005"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70582-X"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2060"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.12.019"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nri3175"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.12.041"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.12.007"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.11.007"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/nature04870"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2941"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2012.03.005"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/846724"},{"key":"14","volume-title":"From HSC to B-lymphoid cells in normal and malignant hematopoiesis","year":"2013"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/349067"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-154187"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/406796"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1816"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36428"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1593\/neo.131310"},{"issue":"2","key":"21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/ng.2874","volume":"46","year":"2014","journal-title":"Nature Genetics"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164390"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.028035"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.72044"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(00)00141-7"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07648.x"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-4135"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.8.2301"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.03.009"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-151506"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.286"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/nature09135"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-380113"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.12.003"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.10.005"},{"key":"36","series-title":"Res Signpost 37\/661 (2)","first-page":"71","volume-title":"Regulation of hematopoietic stem\/progenitor cell development by inflammation cues","year":"2014"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2014.03.008"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302061"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.09.054"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737112"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.03.136"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.03.010"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.01.007"},{"issue":"8","key":"44","first-page":"359","volume":"6","year":"2001","journal-title":"European Journal of Medical Research"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0794"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20869"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2011.05.003"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.01.002"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.11.005"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-11-465252"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-259630"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1038\/nri2726"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-485607"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28198"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2224"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.064907"},{"key":"57","series-title":"Advances in Experimental Medicine and Biology","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-3-0348-0837-8_13","volume-title":"The role of inflammation in leukemia","volume":"816","year":"2014"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/386165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/386165.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/386165.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T07:52:33Z","timestamp":1498204353000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/386165\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":57,"alternative-id":["386165","386165"],"URL":"https:\/\/doi.org\/10.1155\/2015\/386165","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}