{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:49:35Z","timestamp":1740160175183,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Helsinki University Hospital"},{"DOI":"10.13039\/100010125","name":"Jalmari and Rauha Ahokas Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010125","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010135","name":"Finska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010135","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Molecular Imaging"],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"Objectives<\/jats:italic>. Studies comparing outcome of single-T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-methoxyisobutylisonitrile (T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi) and dual-tracer T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi scintigraphy in combination with 123<\/jats:sup>I before primary surgery of primary hyperparathyroidism (PHPT) are scarce. Methods<\/jats:italic>. We compared T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi\/123<\/jats:sup>I and T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi in a single-centre retrospective series of 269 PHPT patients. The results were related to laboratory, surgical and histological findings. Results<\/jats:italic>. T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi\/123<\/jats:sup>I and T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi were positive in 206 (76.6%) and 111 (41.3%) of 269 patients, respectively (P<\/jats:italic> < 0.001). Accuracies for T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi\/123<\/jats:sup>I and T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi were 63.4% and 34.9%, respectively (96% CI, P<\/jats:italic> < 0.001). Prevalence of multiglandular disease was 15.2%. In multiglandular disease, T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi\/123<\/jats:sup>I and T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi revealed 43.8 and 22.1% of pathological glands, respectively (P<\/jats:italic> < 0.001). Cure rate was similar for patients with (191\/206; 92.7%) and without (59 of 63; 93.7%) a positive T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi\/123<\/jats:sup>I finding. Duration of targeted surgery (one or two quadrants) was 21 and 15 minutes shorter than bilateral neck exploration, respectively (both P<\/jats:italic> < 0.001). Higher serum calcium (P<\/jats:italic> = 0.014) and PTH (P<\/jats:italic> = 0.055) concentrations and larger tumours (P<\/jats:italic> < 0.001) characterized the 206 patients with a positive preoperative scan who were cured by removal of a single adenoma. Conclusions<\/jats:italic>. T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi\/123<\/jats:sup>I scintigraphy is more accurate than T<\/mml:mtext><\/mml:mrow>99<\/mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi before surgery of PHPT. However, outcome of surgery is not determined by scintigraphy alone.<\/jats:p>","DOI":"10.1155\/2015\/391625","type":"journal-article","created":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T21:01:27Z","timestamp":1422824487000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["99m<\/sup>Technetium Sestamibi-123<\/sup>Iodine Scintigraphy Is More Accurate Than 99m<\/sup>Technetium Sestamibi Alone before Surgery for Primary Hyperparathyroidism"],"prefix":"10.1155","volume":"2015","author":[{"given":"Eeva M.","family":"Ryh\u00e4nen","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, University of Helsinki, 00029 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Schildt","sequence":"additional","affiliation":[{"name":"HUS Medical Imaging Center, Department of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, 00029 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka","family":"Heiskanen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Helsinki University Central Hospital, 00029 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"V\u00e4is\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Helsinki University Central Hospital, 00029 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aapo","family":"Ahonen","sequence":"additional","affiliation":[{"name":"HUS Medical Imaging Center, Department of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, 00029 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliisa","family":"L\u00f6yttyniemi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Turku, 20520 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Schalin-J\u00e4ntti","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, University of Helsinki, 00029 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti J.","family":"V\u00e4lim\u00e4ki","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, University of Helsinki, 00029 Helsinki, 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