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In this study, the antidepressant-like effect of<jats:italic>Pseudospondias microcarpa<\/jats:italic>extract (30\u2013300\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>,<jats:italic>p.o.<\/jats:italic>) was investigated in two predictive models of depression\u2014forced swimming test and tail suspension test in mice. Additionally, the mechanism(s) of action involved were assessed. Acute treatment with the extract dose dependently reduced immobility of mice in both models. The antidepressant-like effect of the extract (100\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>,<jats:italic>p.o.<\/jats:italic>) was blocked by<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><\/mml:mrow><\/mml:math>-chlorophenylalanine and cyproheptadine but not prazosin, propranolol, or yohimbine. Concomitant administration of<jats:sc>d<\/jats:sc>-cycloserine and the extract potentiated the anti-immobility effect. In contrast,<jats:sc>d<\/jats:sc>-serine, a full agonist of glycine\/NMDA receptors, abolished the effects. Anti-immobility effects of PME were prevented by pretreatment of mice with L-arginine (750\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, i.p.) and sildenafil (5\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, i.p.). On the contrary, pretreatment of mice with L-NAME (30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, i.p.) or methylene blue (10\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, i.p.) potentiated its effects. The extract produces an antidepressant-like effect in the FST and TST that is dependent on the serotoninergic system, NMDA receptor complex, and the nitric oxide pathway.<\/jats:p>","DOI":"10.1155\/2015\/397943","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T23:15:27Z","timestamp":1444691727000},"page":"1-15","source":"Crossref","is-referenced-by-count":21,"title":["Antidepressant-Like Effect of the Leaves of<i>Pseudospondias microcarpa<\/i>in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway"],"prefix":"10.1155","volume":"2015","author":[{"given":"Donatus Wewura","family":"Adongo","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy & Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennedy Kwami 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