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Atherosclerosis is an oxidative stress driven pathophysiological complication where free radical induced oxidative modification of low density lipoprotein (LDL) plays the ground breaking role. Mushrooms have been highly regarded for possessing an antioxidant arsenal. Polyphenolic compounds present in dietary mushrooms seem pertinent in withstanding LDL oxidation en route to controlling atherosclerosis. In this study, the antioxidative effect of five solvent fractions consisting of methanol\u2009:\u2009dichloromethane (M\u2009:\u2009DCM), hexane (HEX), dichloromethane (DCM), ethyl acetate (EA), and aqueous residue (AQ) of<jats:italic>Flammulina velutipes<\/jats:italic>was evaluated. M\u2009:\u2009DCM fraction showed the most potent 2,2-diphenyl-1-picrylhydrazyl radical scavenging effect with IC<jats:sub>50<\/jats:sub>of 0.86\u2009mg\/mL and total phenolic content of 56.36 gallic acid equivalent\/g fraction. In LDL oxidation inhibitory tests, M\u2009:\u2009DCM fraction at 1\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL concentration mostly lengthened the lag time (125\u2009mins) of conjugated diene formation and inhibited the formation of thiobarbituric acid reactive substances (48.71%, at 1\u2009mg\/mL concentration). LC-MS\/MS analyses of M\u2009:\u2009DCM fraction identified the presence of polyphenolic substances protocatechuic acid,<jats:italic>p<\/jats:italic>-coumaric, and ellagic acid. These chain-breaking polyphenolics might impart the antioxidative effects of<jats:italic>F. velutipes<\/jats:italic>. Thus, mushroom-based dietary polyphenolic compounds might be implicated in slowing down the progression of atherosclerosis.<\/jats:p>","DOI":"10.1155\/2015\/403023","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T05:10:14Z","timestamp":1433999414000},"page":"1-10","source":"Crossref","is-referenced-by-count":43,"title":["Antioxidative Effects and Inhibition of Human Low Density Lipoprotein Oxidation<i>In Vitro<\/i>of Polyphenolic Compounds in<i>Flammulina velutipes<\/i>(Golden Needle Mushroom)"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4322-8219","authenticated-orcid":true,"given":"Mohammad Azizur","family":"Rahman","sequence":"first","affiliation":[{"name":"Mushroom Research Centre, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia"},{"name":"Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1340, 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