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More specifically, altered levels of inflammatory cytokines and decreased levels of mitochondrial complex I subunits have been found in the brain and periphery of patients with BD, which could lead to increased production of mitochondrial reactive oxygen species (ROS). Recent studies have shown that mitochondrial production of ROS and inflammation may be closely linked through a redox sensor known as nod-like receptor pyrin domain-containing 3 (NLRP3). Upon sensing mitochondrial release of ROS, NLRP3 assembles the NLRP3 inflammasome, which releases caspase 1 to begin the inflammatory cascade. In this review, we discuss the potential role of the NLRP3 inflammasome as a link between complex I dysfunction and inflammation in BD and its therapeutic implications.<\/jats:p>","DOI":"10.1155\/2015\/408136","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T17:07:22Z","timestamp":1431536842000},"page":"1-10","source":"Crossref","is-referenced-by-count":58,"title":["The Potential Role of the NLRP3 Inflammasome as a Link between Mitochondrial Complex I Dysfunction and Inflammation in Bipolar Disorder"],"prefix":"10.1155","volume":"2015","author":[{"given":"Helena Kyunghee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Toronto, 1 King\u2019s College Circle, Toronto, ON, Canada M5S 1A8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of 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