{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:00:18Z","timestamp":1753884018074,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T00:00:00Z","timestamp":1420502400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To evaluate the long term (48 months) therapeutic efficacy of a soft monobloc mandibular advancement device in adult patients with mild or moderate obstructive sleep apnea. <jats:italic>Methods<\/jats:italic>. The study population comprised 28 patients (6 female and 22 male, mean age 52.2 \u00b1 6.8 years) affected by obstructive sleep apnea. After a baseline medical and somnographic examination, a functional examination of the stomatognathic system, and a questionnaire focused on sleep\u2010related qualities and a daytime somnolence, each patient received an individual device. Two follow\u2010ups were made 6 months (T1) and 48 months (T2) after soft monobloc mandibular advancement device treatment had been initiated, and all initial examinations were repeated. <jats:italic>Results<\/jats:italic>. The statistical analysis showed a significant decrease in body mass index value between T1 and T2 (<jats:italic>\u03c1<\/jats:italic> = 0,012), an increase of Epworth sleepiness scale value between T1 and T2 (<jats:italic>\u03c1<\/jats:italic> = 0,012), and a significant improvement and decrease of apnea\/hypopnea index between T0 and T1 (<jats:italic>\u03c1<\/jats:italic> = 0,010) and between T0 and T2 (<jats:italic>\u03c1<\/jats:italic> = 0,013). <jats:italic>Conclusion<\/jats:italic>. Treatment with the soft monobloc mandibular advancement device is a therapeutic solution with long term and stable effects (48 months) for patients suffering from mild or moderate obstructive sleep apnea.<\/jats:p>","DOI":"10.1155\/2015\/408469","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T21:02:01Z","timestamp":1420578121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long Term Therapeutic Efficacy of a Soft Monobloc Mandibular Advancement Device in Adults  with Obstructive Sleep Apnea"],"prefix":"10.1155","volume":"2015","author":[{"given":"Fabiana","family":"Ballanti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Ranieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-4885","authenticated-orcid":false,"given":"Alberto","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Cozza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,6]]},"reference":[{"key":"e_1_2_9_1_2","unstructured":"European Respiratory Society and European Lung Foundation Lung health in Europe-facts and figures 2003."},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.1.127"},{"key":"e_1_2_9_3_2","first-page":"75","article-title":"Treatment of the obstructive sleep apnea syndrome. 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