{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:04:28Z","timestamp":1773752668659,"version":"3.50.1"},"reference-count":44,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Department of Medicine Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Leprosy caused by<jats:italic>Mycobacterium leprae<\/jats:italic>primarily affects the skin and peripheral nerves. As a human infectious disease, it is still a significant health and economic burden on developing countries. Although multidrug therapy is reducing the number of active cases to approximately 0.5 million, the number of cases per year is not declining. Therefore, alternative host-directed strategies should be addressed to improve treatment efficacy and outcome. In this work, using murine leprosy as a model, a very similar granulomatous skin lesion to human leprosy, we have found that successive IFN-alpha boosting protects BCG-vaccinated mice against<jats:italic>M. lepraemurium<\/jats:italic>infection. No difference in the seric isotype and all IgG subclasses measured, neither in the TH1 nor in the TH2 type cytokine production, was seen. However, an enhanced iNOS\/NO production in BCG-vaccinated\/i.m. IFN-alpha boosted mice was observed. The data provided in this study suggest a promising use for IFN-alpha boosting as a new prophylactic alternative to be explored in human leprosy by targeting host innate cell response.<\/jats:p>","DOI":"10.1155\/2015\/414027","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T21:02:26Z","timestamp":1442869346000},"page":"1-9","source":"Crossref","is-referenced-by-count":9,"title":["Successive Intramuscular Boosting with IFN-Alpha Protects<i>Mycobacterium bovis<\/i>BCG-Vaccinated Mice against<i>M. lepraemurium<\/i>Infection"],"prefix":"10.1155","volume":"2015","author":[{"given":"G. G.","family":"Guerrero","sequence":"first","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma de Zacatecas, Avenida Preparatoria, S\/N, Colonia Agronomicas, 98066 Zacatecas, ZAC, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rangel-Moreno","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Islas-Trujillo","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Carpio y Plan de Ayala, Colonia Santo Tomas, 11340 Mexico City, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d3.","family":"Rojas-Espinosa","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Carpio y Plan de Ayala, Colonia Santo Tomas, 11340 Mexico City, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2471\/blt.06.039206"},{"issue":"10","key":"2","first-page":"962","volume":"39","year":"2001","journal-title":"Indian Journal of Experimental Biology"},{"key":"3","year":"2012"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1128\/cvi.00432-07"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103452"},{"key":"6","first-page":"97","volume-title":"Murine leprosy 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