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We investigated the role of fasting serum amino acids and their associations with inflammatory markers, adipokines, and metabolic syndrome (MetS) components in subjects prior to the onset of insulin resistance (IR). Anthropometric measurements, food records, adipokines, biochemical markers, and serum levels of amino acids were determined in 96 asymptomatic subjects aged 25\u201349 years divided into three groups according to the number of MetS components present. Cysteine and tyrosine were significantly higher already in group with one component of MetS present compared to subjects without MetS components. Serum amino acid levels correlated with markers of inflammation and adipokines. Alanine and glycine explained 10% of insulin resistance variability. The role of tyrosine and cysteine, that were higher already with 1 component of MetS present, should be further investigated as they might point to future insulin disturbances.<\/jats:p>","DOI":"10.1155\/2015\/418681","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T21:00:56Z","timestamp":1425502856000},"page":"1-14","source":"Crossref","is-referenced-by-count":46,"title":["Elevated Serum Levels of Cysteine and Tyrosine: Early Biomarkers in Asymptomatic Adults at Increased Risk of Developing Metabolic Syndrome"],"prefix":"10.1155","volume":"2015","author":[{"given":"Nina","family":"Mohorko","sequence":"first","affiliation":[{"name":"Science and Research Centre, University of Primorska, Garibaldijeva 1, SI-6000 Koper, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Petelin","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Primorska, Polje 42, SI-6310 Izola, 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