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Fifty Wistar female rats used were divided into 5 groups: (1) sham-operation rats (control), (2) ovariectomized (OVX) rats with osteopenia, and (3) OVX\u2019d rats with osteopenia treated with cordycepin (5\u2009mg, 10\u2009mg, and 20\u2009mg) for 8 weeks. After the rats were treated orally with cordycepin, serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine (HCY) , C-terminal crosslinked telopeptides of collagen type I (CTX) level, and oxidative stress were examined, respectively. The femoral neck was used for mechanical compression testing. At the same time, we further investigated the effect of cordycepin<jats:italic>in vitro<\/jats:italic>assay. The beneficial effects of cordycepin on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, and CTX level. At the same time, cordycepin also increases the OC level in ovariectomized osteopenic rats. The histological examination clearly showed that dietary cordycepin can prevent bone loss caused by estrogen deficiency. These experimental results suggest that complement cordycepin is protective after ovariectomized osteopenic in specific way.<\/jats:p>","DOI":"10.1155\/2015\/423869","type":"journal-article","created":{"date-parts":[[2015,3,22]],"date-time":"2015-03-22T21:04:17Z","timestamp":1427058257000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Osteoprotective Effect of Cordycepin on Estrogen Deficiency-Induced Osteoporosis<i>In Vitro<\/i>and<i>In Vivo<\/i>"],"prefix":"10.1155","volume":"2015","author":[{"given":"Da-wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Xi Jing Hospital, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualiang","family":"Deng","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, Jinan 250355, 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