{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:04:02Z","timestamp":1789704242877,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose.<\/jats:italic>To investigate the role of systemic arterial stiffness in glaucoma patients with diabetes mellitus (DM).<jats:italic>Design.<\/jats:italic>Retrospective, cross-sectional study.<jats:italic>Participants.<\/jats:italic>DM subjects who underwent brachial-ankle pulse wave velocity (baPWV) were recruited.<jats:italic>Methods.<\/jats:italic>Glaucoma patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>75<\/mml:mn><\/mml:math>) and age-matched control subjects (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>92<\/mml:mn><\/mml:math>) were enrolled. Systemic examination including BaPWV and detailed eye examination were performed. The glaucoma group was divided into subgroups of normal tension glaucoma (NTG,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>55<\/mml:mn><\/mml:math>) and primary open-angle glaucoma (POAG) based on an IOP of 21\u2009mmHg. BaPWV was used to stratify the population into 4 groups based on the rate. Stepwise multiple logistic regression analysis by baPWV quartiles was used to compare the glaucoma group with the control group.<jats:italic>Main Outcome Measures.<\/jats:italic>BaPWV in glaucoma with DM patients.<jats:italic>Results.<\/jats:italic>Faster baPWV was positively associated with glaucoma (odds ratio: 3.74; 95% CI: 1.03\u201313.56, stepwise multiple logistic regression analysis) in patients with DM. Increasing baPWV was also positively associated with glaucoma (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>p<\/mml:mi><\/mml:mrow><\/mml:math>for trend = 0.036). The NTG subgroup showed similar results to those of the glaucoma group.<jats:italic>Conclusions.<\/jats:italic>In this study, increased arterial stiffness was shown to be associated with glaucoma and may contribute to the pathogenesis of glaucoma in DM patients.<\/jats:p>","DOI":"10.1155\/2015\/425835","type":"journal-article","created":{"date-parts":[[2015,10,18]],"date-time":"2015-10-18T17:02:33Z","timestamp":1445187753000},"page":"1-8","source":"Crossref","is-referenced-by-count":22,"title":["The Role of Systemic Arterial Stiffness in Open-Angle Glaucoma with Diabetes Mellitus"],"prefix":"10.1155","volume":"2015","author":[{"given":"Seong Hee","family":"Shim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Yun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da Yeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hun","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Chul","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of 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