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Patients may respond differently to PCM depending on the pattern of the acquired immune response developed. The onset of protective immune response is notably mediated by neutrophils (PMN) that play an important role through directly killing the fungi and also by interacting with other cell types to modulate the acquired protective immune response that may follow. In that way, this study aimed to present and compare different experimental models of PCM (intraperitoneal and subcutaneous) regarding PMN production and maturation inside femoral bone marrow and also PMN infiltration in peritoneal and subcutaneous exudates of resistant and susceptible mice. We also assessed the fungal colony forming units and the levels of soluble inflammatory mediators (LTB4, KC, IFN\u2010<jats:italic>\u03b3<\/jats:italic>, GM\u2010CSF, and IL\u201010) inside subcutaneous air\u2010pouches to compare the efficiency of the PMN present at this site in relation to the two main neutrophil functions: initial lysis of the invading pathogen and modulation of the acquired immune response. <jats:italic>P. brasiliensis<\/jats:italic> inoculated intraperitoneally was able to disseminate to the bone marrow of susceptible mice, causing a more marked alteration of PMN production and maturation than that observed after resistant mice infection by the same route. Subcutaneous air\u2010pouch inoculation of <jats:italic>P. brasiliensis<\/jats:italic> elicited a controlled and limited infection that produced a PMN\u2010rich exudate, thus favoring the study of the interaction between the fungus and the neutrophils. Susceptible mice produced higher numbers of PMN; however, these cells were less effective in killing the fungi. Inflammatory cytokines were more pronounced in resistant mice, which supports their PCM raised resistance.<\/jats:p>","DOI":"10.1155\/2015\/430525","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T21:31:35Z","timestamp":1450992695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Resistance to <i>P. brasiliensis<\/i> Experimental Infection of Inbred Mice Is Associated with an Efficient Neutrophil Mobilization and Activation by Mediators of Inflammation"],"prefix":"10.1155","volume":"2015","author":[{"given":"Felipe Fornias","family":"Sperandio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele Pesquero","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Silv\u00e9rio Cerqueira","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia Maria de Alencar Castro","family":"Bani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera Lucia Garcia","family":"Calich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Burger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,24]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20132463"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12325"},{"key":"e_1_2_9_3_2","first-page":"e44","article-title":"Difficulty in diagnosing oral paracoccidioidomycosis after topical nystatin usage","volume":"60","author":"Sperandio F. 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