{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:03:07Z","timestamp":1740164587862,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270641","81200400","20123518120006"],"award-info":[{"award-number":["81270641","81200400","20123518120006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270641","81200400","20123518120006"],"award-info":[{"award-number":["81270641","81200400","20123518120006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Doctoral Fund of Ministry of Education","award":["81270641","81200400","20123518120006"],"award-info":[{"award-number":["81270641","81200400","20123518120006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Ultra early posttransplantation lymphoproliferative disorder (PTLD) is a rare and fatal complication after hematopoietic stem cell transplantation (HSCT). Here we report, by lymph node (LN) flowcytometry, that we early recognized ultra early PTLD after an HLA-matched sibling allo-HSCT followed by a successful treatment with anti-CD20 antibody (rituximab) in a patient in progress disease for angioimmunoblastic T-cell lymphoma (AITL). The patient was conditioned with a reduced intensity conditioning (RIC) regimen. One week after transplantation, the patient developed high fever, generalized fatigue, high Epstein-Barr virus (EBV) load, and LN enlargement. An LN lymphocyte suspension and peripheral blood flowcytometry was performed to find majority of LN lymphocytes highly expressed CD20. By highly suspicious PTLD, 4 doses of rituximab (375\u2009mg\/m<jats:sup>2<\/jats:sup>\u2009qw) were given immediately followed by reducing and withdrawing immunosuppressant reagent. PTLD was later confirmed by pathology. The patient had good response to rituximab, showing absence of fever, reduction in LN size, and no detectable EBV-DNA. Twenty months after HSCT, the patient remains well without evidence of AITL and PTLD. The current report is one of the earliest cases of PTLD after HSCT. Taken together, by LN flowcytometry as a prompt recognition, rituximab can be an effective preemptive therapy for ultra early developed PTLD.<\/jats:p>","DOI":"10.1155\/2015\/430623","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T23:32:31Z","timestamp":1427239951000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Lymph Node Flow Cytometry as a Prompt Recognition of Ultra Early Onset PTLD: A Successful Case of Rituximab Treatment"],"prefix":"10.1155","volume":"2015","author":[{"given":"Xiaofan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nainong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhizhe","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianda","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141606"},{"issue":"7","key":"2","first-page":"2208","volume":"94","year":"1999","journal-title":"Blood"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.121270"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1182\/blood.V85.5.1396.bloodjournal8551396","volume":"85","year":"1995","journal-title":"Blood"},{"issue":"1","key":"5","first-page":"2","volume":"14","year":"1997","journal-title":"Seminars in Diagnostic Pathology"},{"issue":"1","key":"6","first-page":"8","volume":"14","year":"1997","journal-title":"Seminars in Diagnostic Pathology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701468"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200104270-00012"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit391"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-371971"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-239186"},{"issue":"3","key":"12","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1200\/JCO.2001.19.3.772","volume":"19","year":"2001","journal-title":"Journal of Clinical Oncology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.302"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03041.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1080\/10428190400012011"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2015\/430623.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2015\/430623.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2015\/430623.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T04:28:40Z","timestamp":1598848120000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crihem\/2015\/430623\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":15,"alternative-id":["430623","430623"],"URL":"https:\/\/doi.org\/10.1155\/2015\/430623","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2015]]}}}