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UC-MSCs were isolated from Wharton\u2019s jelly (WJ) of umbilical cords. An irradiated cervical spinal cord rat model (C2-T2 segment) was generated using a<jats:sup>60<\/jats:sup>Co irradiator to deliver 30\u2009Gy of radiation. UC-MSCs were injected through the tail vein at 90 days, 97 days, 104 days, and 111 days after-irradiation. Histological damage was examined by cresyl violet\/Nissl staining. The activities of two antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPX) in the spinal cord were measured by the biomedical assay. In addition, the levels of vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) in the spinal cord were determined by ELISA methods. Multiple injections of UC-MSCs through the tail vein ameliorated neuronal damage in the spinal cord, increased the activities of the antioxidant enzymes CAT and GPX, and increased the levels of VEGF and Ang-2 in the spinal cord. Our results suggest that multiple injections of UC-MSCs via the tail vein in the rat model of radiation myelopathy could significantly improve the antioxidative microenvironment in vivo.<\/jats:p>","DOI":"10.1155\/2015\/432369","type":"journal-article","created":{"date-parts":[[2015,8,23]],"date-time":"2015-08-23T17:24:17Z","timestamp":1440350657000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy"],"prefix":"10.1155","volume":"2015","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Liaoning Medical University, No. 2 Renmin Street, Guta District, Jinzhou, Liaoning 121000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian-Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Reproductive Health of The 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