{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:19Z","timestamp":1787017819202,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . The Sj\u00f6gren Syndrome (SS) can include various manifestations of central nervous system impairment. Extrapyramidal signs are known to be very rare and unusually discovered on early onset in this pathology.\n                    <jats:italic>Observation<\/jats:italic>\n                    . A 46-year-old woman with a history of progressive Parkinsonism for 6 years and a normal brain magnetic resonance imaging was partially improved with levodopa therapy. The later discovery of a sicca syndrome led to performing of further investigations, which revealed the presence of anti-SSA antibodies and a sialoadenitis of grade 4 according to Chisholm\u2019s classification on labial salivary gland biopsy. The diagnosis of primary SS was established and the adjunction of corticotherapy has remarkably improved Parkinson\u2019s signs without use of other immunosuppressive agents.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Based on these findings, we discuss the hypothesis of either a causal link between SS and Parkinsonism or a fortuitous association of two distinct pathologies with or without a shared immunopathogenesis.\n                  <\/jats:p>","DOI":"10.1155\/2015\/432910","type":"journal-article","created":{"date-parts":[[2015,5,31]],"date-time":"2015-05-31T17:02:48Z","timestamp":1433091768000},"page":"1-4","source":"Crossref","is-referenced-by-count":10,"title":["Parkinsonism and Sj\u00f6gren\u2019s Syndrome: A Fortuitous Association or a Shared Immunopathogenesis?"],"prefix":"10.1155","volume":"2015","author":[{"given":"Mariem","family":"Kchaou","sequence":"first","affiliation":[{"name":"Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, Beb Souika, 1016 Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Ben Ali","sequence":"additional","affiliation":[{"name":"Neurological 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