{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:18:13Z","timestamp":1740140293914,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173226","61202238","201406020044"],"award-info":[{"award-number":["81173226","61202238","201406020044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173226","61202238","201406020044"],"award-info":[{"award-number":["81173226","61202238","201406020044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["81173226","61202238","201406020044"],"award-info":[{"award-number":["81173226","61202238","201406020044"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Unlike the western medical approach where a drug is prescribed against specific symptoms of patients, traditional Chinese medicine (TCM) treatment has a unique step, which is called syndrome differentiation (SD). It is argued that SD is considered as patient classification because prior to the selection of the most appropriate formula from a set of relevant formulae for personalization, a practitioner has to label a patient belonging to a particular class (syndrome) first. Hence, to detect the patterns between herbs and symptoms via syndrome is a challenging problem; finding these patterns can help prepare a prescription that contributes to the efficacy of a treatment. In order to highlight this unique triangular relationship of symptom, syndrome, and herb, we propose a novel three-step mining approach. It first starts with the construction of a heterogeneous tripartite information network, which carries richer information. The second step is to systematically extract path-based topological features from this tripartite network. Finally, an unsupervised method is used to learn the best parameters associated with different features in deciding the symptom-herb relationships. Experiments have been carried out on four real-world patient records (Insomnia, Diabetes, Infertility, and Tourette syndrome) with comprehensive measurements. Interesting and insightful experimental results are noted and discussed.<\/jats:p>","DOI":"10.1155\/2015\/435085","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T12:08:25Z","timestamp":1433938105000},"page":"1-14","source":"Crossref","is-referenced-by-count":7,"title":["Mining Symptom-Herb Patterns from Patient Records Using Tripartite Graph"],"prefix":"10.1155","volume":"2015","author":[{"given":"Jinpeng","family":"Chen","sequence":"first","affiliation":[{"name":"School of Computer Science and Engineering, BeiHang University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josiah","family":"Poon","sequence":"additional","affiliation":[{"name":"School of Information and Technologies, University of Sydney, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon K.","family":"Poon","sequence":"additional","affiliation":[{"name":"School of Information and Technologies, University of Sydney, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M. Y.","family":"Sze","sequence":"additional","affiliation":[{"name":"RMIT University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(08)61354-9"},{"volume":"15","journal-title":"Computer Engineering","year":"2006","key":"22"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1142\/s0218339009002971"},{"issue":"1","key":"24","first-page":"4","volume":"28","year":"2005","journal-title":"Journal of Beijing University of Traditional Chinese Medicine"},{"first-page":"258","volume-title":"Novel two-stage analytic approach in extraction of strong herb-herb interactions in TCM clinical treatment of insomnia","year":"2010","key":"1"},{"issue":"11","key":"5","first-page":"992","volume":"4","year":"2011","journal-title":"PVLDB"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5439.509"},{"issue":"8","key":"9","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/BF00220804","volume":"88","year":"1994","journal-title":"Theoretical and Applied Genetics"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/11574620_38"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.14311\/nnw.2014.24.017"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-011-0842-8"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1504\/ijdmb.2011.041553"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/435085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/435085.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/435085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T08:46:51Z","timestamp":1566809211000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2015\/435085\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":12,"alternative-id":["435085","435085"],"URL":"https:\/\/doi.org\/10.1155\/2015\/435085","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"type":"print","value":"1741-427X"},{"type":"electronic","value":"1741-4288"}],"subject":[],"published":{"date-parts":[[2015]]}}}