{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:07Z","timestamp":1740169747098,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To compare the ocular pulse amplitude (OPA) lowering effects of preservative-free tafluprost and dorzolamide-timolol fixed combination (DTFC) using dynamic contour tonometry.<jats:italic>Methods<\/jats:italic>. In total, 66 eyes of 66 patients with normal tension glaucoma (NTG) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>34<\/mml:mn><\/mml:math>) or primary open angle glaucoma (POAG) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>32<\/mml:mn><\/mml:math>) were included. Patients were divided into two groups: the preservative-free tafluprost-treated group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>33<\/mml:mn><\/mml:math>) and the preservative-free DTFC-treated group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>33<\/mml:mn><\/mml:math>). Intraocular pressure (IOP) was measured using Goldmann applanation tonometry (GAT). OPA was measured using dynamic contour tonometry; corrected OPA (cOPA) was calculated at baseline and at 1 week and 1, 3, and 6 months after treatment.<jats:italic>Results<\/jats:italic>. After 6 months of treatment, tafluprost significantly reduced IOP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). The OPA lowering effects differed significantly between the two treatment groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>). The cOPA-lowering effect of tafluprost (1.09\u2009mmHg) was significantly greater than that of DTFC (0.36\u2009mmHg) after 6 months of treatment (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Tafluprost and DTFC glaucoma treatments provided marked OPA and IOP lowering effects. Tafluprost had a greater effect than DTFC; thus, this drug is recommended for patients at risk of glaucoma progression, due to the high OPA caused by large fluctuations in IOP.<\/jats:p>","DOI":"10.1155\/2015\/435874","type":"journal-article","created":{"date-parts":[[2015,10,18]],"date-time":"2015-10-18T17:02:43Z","timestamp":1445187763000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Ocular Pulse Amplitude Lowering Effects of Preservative-Free Tafluprost and Preservative-Free Dorzolamide-Timolol Fixed Combination Eyedrops"],"prefix":"10.1155","volume":"2015","author":[{"given":"Du Ri","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Soonchunhyang University College of Medicine, Soonchunhyang University Seoul Hospital, Seoul 140-743, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Joo","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Soonchunhyang University College of Medicine, Soonchunhyang University Seoul Hospital, Seoul 140-743, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2012.02773.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/icu.0b013e3282f3919b"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(01)00964-3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2014.07.008"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.01954.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31815c5f2c"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2007.0065"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02768.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S41640"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S6369"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1397-7"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.8.1104"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2011.584652"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200004000-00002"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2009.77"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/s1350-9462(02)00008-3"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0018"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000176936.16015.4e"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01604.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3341\/jkos.2014.55.6.854"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31806ab2fe"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-007-0706-2"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2009.0100"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1159\/000356468"},{"issue":"2","key":"24","first-page":"186","volume":"22","year":"1999","journal-title":"Journal Francais d'Ophtalmologie"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.492030"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2011.05.015"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.4137\/oed.s4253"},{"issue":"1","key":"28","first-page":"163","volume":"4","year":"2010","journal-title":"Clinical Ophthalmology"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2010.09.004"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/435874.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/435874.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/435874.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T07:49:50Z","timestamp":1469605790000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/435874\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":30,"alternative-id":["435874","435874"],"URL":"https:\/\/doi.org\/10.1155\/2015\/435874","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2015]]}}}