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Synovial fibroblasts and T cells participate in the perpetuation of joint inflammation in a mutual activation feedback, via secretion of cytokines and chemokines that stimulate each other. IL\u201017 is an inflammatory cytokine produced primarily by Th17 cells which plays critical role in the pathogenesis of numerous autoimmune and inflammatory diseases. Here, we investigated the roles of IL\u201017A in temporomandibular joint disorders (TMD) using genome\u2010wide analysis of synovial fibroblasts isolated from patients with TMD. IL\u201017 receptors were expressed in synovial fibroblasts as assessed using real\u2010time PCR. Microarray analysis indicated that IL\u201017A treatment of synovial fibroblasts upregulated the expression of IL\u20106 and chemokines. Real\u2010time PCR analysis showed that the gene expression of IL\u20106, CXCL1, IL\u20108, and CCL20 was significantly higher in IL\u201017A\u2010treated synovial fibroblasts compared to nontreated controls. IL\u20106 protein production was increased by IL\u201017A in a time\u2010 and a dose\u2010dependent manner. Additionally, IL\u201017A simulated IL\u20106 protein production in synovial fibroblasts samples isolated from three patients. Furthermore, signal inhibitor experiments indicated that IL\u201017\u2010mediated induction of IL\u20106 was transduced via activation of NF<jats:italic>\u03ba<\/jats:italic>B and phosphatidylinositol 3\u2010kinase\/Akt. These results suggest that IL\u201017A is associated with the inflammatory progression of TMD.<\/jats:p>","DOI":"10.1155\/2015\/436067","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T21:02:59Z","timestamp":1451422979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Gene Expression Profiling of IL\u201017A\u2010Treated Synovial Fibroblasts from the Human Temporomandibular 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