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As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transplantation. Therefore alternative therapies are highly desirable and cell-based therapies have been investigated in preclinical and clinical studies. In this paper we review the main findings of such studies and discuss future directions for stem cell-based therapies in chronic chagasic cardiomyopathy.<\/jats:p>","DOI":"10.1155\/2015\/436314","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T17:01:42Z","timestamp":1434387702000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Stem Cell-Based Therapies in Chagasic Cardiomyopathy"],"prefix":"10.1155","volume":"2015","author":[{"given":"Antonio Carlos","family":"Campos de Carvalho","sequence":"first","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rua Carlos Chagas Filho 373, 21949-900 Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Bastos Carvalho","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rua Carlos Chagas Filho 373, 21949-900 Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1590\/s0074-02761909000200008"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.046"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/nature09221"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(10)60061-x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2009.02.001"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.624296"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)63134-3"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1086\/526793"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.9.15487"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.000646"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/stem.459"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1172\/jci5298"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001971"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2014.08.016"},{"issue":"2","key":"15","first-page":"159","volume":"87","year":"2006","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-137869"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.02.008"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.067785"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000604"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.08.013"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.09.007"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/s0020-7519(01)00320-4"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-005-1409-4"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.245993"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa060186"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.25321"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000138398.77550.62"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2009.01.004"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.11.022"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.02.002"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/436314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/436314.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/436314.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T14:21:11Z","timestamp":1471530071000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/436314\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":30,"alternative-id":["436314","436314"],"URL":"https:\/\/doi.org\/10.1155\/2015\/436314","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2015]]}}}