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Immunohistochemistry was used to detect HE4 expression in 102 cases of endometrial cancer, 30 cases of endometrial atypical hyperplasia, and 20 cases of normal endometrium. The positive expression rate of HE4 in endometrial carcinoma was 84.62%, significantly higher than 66.67% in atypical hyperplasia (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>05<\/mml:mn><\/mml:math>) and 15.00% in normal endometrium (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). With the exception of stage II, HE4 expression in endometrial cancer showed an increasing tendency with increased clinical stage (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>05<\/mml:mn><\/mml:math>). The positive expression rate of HE4 increased with a decrease in the degree of differentiation. A statistically significant difference was observed between the highly differentiated group and the poorly differentiated group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>05<\/mml:mn><\/mml:math>). Mortality in endometrial cancer patients with high HE4 expression was significantly higher than that in patients with low HE4 expression (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>05<\/mml:mn><\/mml:math>). Endometrial cancer patients with high HE4 expression have a poor prognosis.<\/jats:p>","DOI":"10.1155\/2015\/437468","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T19:16:43Z","timestamp":1444677403000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Expression of HE4 in Endometrial Cancer and Its Clinical Significance"],"prefix":"10.1155","volume":"2015","author":[{"given":"Xiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiping","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, 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