{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:54:29Z","timestamp":1771383269493,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":252,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Pityriasis rosea (PR) is an exanthematous disease related to human herpesvirus\u2010 (HHV\u2010) 6\/7 reactivation. The network of mediators involved in recruiting the infiltrating inflammatory cells has never been studied. <jats:italic>Object<\/jats:italic>. To investigate the levels of serum cytokines, growth factors, and chemokines in PR and healthy controls in order to elucidate the PR pathogenesis. <jats:italic>Materials and Methods<\/jats:italic>. Interleukin\u2010 (IL\u2010) 1, IL\u20106, IL\u201017, interferon\u2010 (IFN\u2010) <jats:italic>\u03b3<\/jats:italic>, tumor necrosis factor\u2010 (TNF\u2010) <jats:italic>\u03b1<\/jats:italic>, vascular endothelial growth factor (VEGF), granulocyte colony stimulating factor (G\u2010CSF), and chemokines, CXCL8 (IL\u20108) and CXCL10 (IP\u201010), were measured simultaneously by a multiplex assay in early acute PR patients\u2019 sera and healthy controls. Subsequently, sera from PR patients were analysed at 3 different times (0, 15, and 30 days). <jats:italic>Results and discussion<\/jats:italic>. Serum levels of IL\u201017, IFN\u2010<jats:italic>\u03b3<\/jats:italic>, VEGF, and IP\u201010 resulted to be upregulated in PR patients compared to controls. IL\u201017 has a key role in host defense against pathogens stimulating the release of proinflammatory cytokines\/chemokines. IFN\u2010<jats:italic>\u03b3<\/jats:italic> has a direct antiviral activity promoting NK cells and virus specific T cells cytotoxicity. VEGF stimulates vasculogenesis and angiogenesis. IP\u201010 can induce chemotaxis, apoptosis, cell growth, and angiogenesis. <jats:italic>Conclusions<\/jats:italic>. Our findings suggest that these inflammatory mediators may modulate PR pathogenesis in synergistic manner.<\/jats:p>","DOI":"10.1155\/2015\/438963","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T04:18:01Z","timestamp":1441945081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The Role of Cytokines, Chemokines, and Growth Factors in the Pathogenesis of Pityriasis Rosea"],"prefix":"10.1155","volume":"2015","author":[{"given":"Francesco","family":"Drago","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Ciccarese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Broccolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Ghio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Contini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajdhica","family":"Thanasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Parodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,10]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)63203-5"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00658.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.00200.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23719.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.045"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03778.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03469.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01721.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.03067.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0300-9475.2004.01432.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf02725664"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0928-0197(95)00005-S"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.11.011"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.01.014"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.11.012"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1461"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr110"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05505"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.10.009"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.125"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.06573-11"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2014.26.4.522"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.03.041"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/v5123109"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091385"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2012.0011"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.2.585-594.2004"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.79.17.11457-11466.2005"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2015\/438963.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2015\/438963.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2015\/438963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T21:58:05Z","timestamp":1722895085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2015\/438963"}},"subtitle":[],"editor":[{"given":"Cristiana C.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1155\/2015\/438963"],"URL":"https:\/\/doi.org\/10.1155\/2015\/438963","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2015-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"438963"}}