{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:39Z","timestamp":1787017719409,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    <jats:italic>Purpose<\/jats:italic>\n                    . Macrophages serve as sweepers of microbes and inflammation-derived wastes and regulators of inflammation. Some traditional Japanese medicines are reported to have adjuvant effects by modifying macrophages. Our aim was to characterize the actions of jumihaidokuto (JHT) for treatment of skin inflammations including acne vulgaris, in which\n                    <jats:italic>Propionibacterium acnes<\/jats:italic>\n                    has pathogenic roles.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Dermatitis was induced in rat ears by intradermal injection of\n                    <jats:italic>P. acnes<\/jats:italic>\n                    . JHT or prednisolone (PDN) was given orally, and ear thickness and histology were evaluated. The effects of constituents and metabolites of JHT on monocytes were tested by cell-based assays using the human monocytic THP-1 cell.\n                    <jats:italic>Results<\/jats:italic>\n                    . JHT and PDN suppressed the ear thickness induced by\n                    <jats:italic>P. acnes<\/jats:italic>\n                    injection. Histological examinations revealed that JHT, but not PDN, promoted macrophage accumulation at 24\u2009h after the injection. PDN suppressed the macrophage chemokine MCP-1 in the inflamed ears, while JHT did not affect it. The JHT constituents liquiritigenin and isoliquiritin increased expression of CD86 (type-1 macrophage marker) and CD192 (MCP-1 receptor) and enhanced phagocytosis by THP-1.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . JHT suppressed dermatitis, probably by enhancing type-1 macrophage functions, with an action different from PDN. JHT may be a beneficial drug in treatment of skin inflammation induced by\n                    <jats:italic>P. acnes<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1155\/2015\/439258","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T17:14:54Z","timestamp":1443719694000},"page":"1-10","source":"Crossref","is-referenced-by-count":12,"title":["Suppression of\n                    <i>Propionibacterium acnes<\/i>\n                    -Induced Dermatitis by a Traditional Japanese Medicine, Jumihaidokuto, Modifying Macrophage Functions"],"prefix":"10.1155","volume":"2015","author":[{"given":"Kyoji","family":"Sekiguchi","sequence":"first","affiliation":[{"name":"Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Koseki","sequence":"additional","affiliation":[{"name":"Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Imamura","sequence":"additional","affiliation":[{"name":"Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4392-912X","authenticated-orcid":true,"given":"Atsushi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.12.004"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.505"},{"issue":"9","key":"3","first-page":"27","volume":"6","year":"2013","journal-title":"The Journal of Clinical and Aesthetic Dermatology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4785"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00614"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-013-0941-0"},{"issue":"5","key":"7","first-page":"193","volume":"28","year":"2002","journal-title":"Drugs under Experimental and Clinical Research"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.22.48"},{"key":"9","first-page":"452","volume":"11","year":"1994","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.215.43"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2005.01.004"},{"issue":"6","key":"12","first-page":"4109","volume":"20","year":"2000","journal-title":"Anticancer Research"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2684"},{"issue":"9","key":"14","first-page":"445","volume":"58","year":"2008","journal-title":"Arzneimittel-Forschung"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2362"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1021\/jf000089s"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.22.326"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12264715"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2011.0307"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.163"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2013.06.010"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2015.02.007"},{"issue":"21","key":"23","first-page":"2695","volume":"34","year":"2009","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.141481"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2011.00956.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12812"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12168"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.79"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-967126"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/853846"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2006.06.004"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.03.109"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.12.010"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2012.702756"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/439258.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/439258.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/439258.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T15:32:22Z","timestamp":1471534342000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2015\/439258\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":34,"alternative-id":["439258","439258"],"URL":"https:\/\/doi.org\/10.1155\/2015\/439258","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}