{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:11:27Z","timestamp":1789229487047,"version":"build-2803163510"},"reference-count":87,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Syncytiotrophoblast lines the intervillous space of the placenta and plays important roles in fetus growth throughout gestation. However, perturbations at the maternal-fetal interface during placental malaria may possibly alter the physiological functions of syncytiotrophoblast and therefore growth and development of the embryo<jats:italic>in utero<\/jats:italic>. An understanding of the influence of placental malaria on syncytiotrophoblast function is paramount in developing novel interventions for the control of placental pathology associated with placental malaria. In this review, we discuss how malaria changes syncytiotrophoblast function as evidenced from human, animal, and<jats:italic>in vitro<\/jats:italic>studies and, further, how dysregulation of syncytiotrophoblast function may impact fetal growth<jats:italic>in utero<\/jats:italic>. We also formulate a hypothesis, stemming from epidemiological observations, that nutrition may override pathogenesis of placental malaria-associated-fetal growth restriction. We therefore recommend studies on nutrition-based-interventional approaches for high placental malaria-risk women in endemic areas. More investigations on the role of nutrition on placental malaria pathogenesis are needed.<\/jats:p>","DOI":"10.1155\/2015\/451735","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T21:13:20Z","timestamp":1445894000000},"page":"1-9","source":"Crossref","is-referenced-by-count":28,"title":["Syncytiotrophoblast Functions and Fetal Growth Restriction during Placental Malaria: Updates and Implication for Future Interventions"],"prefix":"10.1155","volume":"2015","author":[{"given":"Winifrida B.","family":"Kidima","sequence":"first","affiliation":[{"name":"Department of Zoology, College of Natural and Applied Science, University of Dar es Salaam, P.O. 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