{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:04:07Z","timestamp":1791443047981,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:00:00Z","timestamp":1443484800000},"content-version":"vor","delay-in-days":271,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["175053"],"award-info":[{"award-number":["175053"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Serbian Ministry of Education, Science and Technological Development","award":["175053"],"award-info":[{"award-number":["175053"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    The recent JAK1\/2 inhibitor trial in myeloproliferative neoplasms (MPNs) showed that reducing inflammation can be more beneficial than targeting gene mutants. We evaluated the proinflammatory IL\u20106 cytokine and JAK\u2010STAT signaling pathway related genes in circulating CD34\n                    <jats:sup>+<\/jats:sup>\n                    cells of MPNs. Regarding laboratory data, leukocytosis has been observed in polycythemia vera (PV) and\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F mutation positive versus negative primary myelofibrosis (PMF) patients. Moreover, thrombocytosis was reduced by\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F allele burden in essential thrombocythemia (ET) and PMF. 261 significantly changed genes have been detected in  PV, 82 in ET, and 94 genes in PMF. The following JAK\u2010STAT signaling pathway related genes had augmented expression in CD34\n                    <jats:sup>+<\/jats:sup>\n                    cells of MPNs:\n                    <jats:italic>CCND3<\/jats:italic>\n                    and\n                    <jats:italic>IL23A<\/jats:italic>\n                    regardless of\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F allele burden;\n                    <jats:italic>CSF3R, IL6ST<\/jats:italic>\n                    , and\n                    <jats:italic>STAT1\/2<\/jats:italic>\n                    in ET and PV with\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F mutation; and\n                    <jats:italic>AKT2, IFNGR2, PIM1, PTPN11<\/jats:italic>\n                    , and\n                    <jats:italic>STAT3<\/jats:italic>\n                    only in PV.\n                    <jats:italic>STAT5A<\/jats:italic>\n                    gene expression was generally reduced in MPNs. IL\u20106 cytokine levels were increased in plasma, as well as IL\u20106 protein levels in bone marrow stroma of MPNs, dependent on\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F mutation presence in ET and PMF patients. Therefore, the\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F mutant allele burden participated in inflammation biomarkers induction and related signaling pathways activation in MPNs.\n                  <\/jats:p>","DOI":"10.1155\/2015\/453020","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T17:06:44Z","timestamp":1443546404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Proinflammatory Cytokine IL\u20106 and JAK\u2010STAT Signaling Pathway in Myeloproliferative Neoplasms"],"prefix":"10.1155","volume":"2015","author":[{"given":"Vladan P.","family":"\u010coki\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivera","family":"Mitrovi\u0107-Ajti\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana 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