{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:08:52Z","timestamp":1773274132684,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003712","name":"Korean Food Research Institute","doi-asserted-by":"crossref","award":["K14281"],"award-info":[{"award-number":["K14281"]}],"id":[{"id":"10.13039\/501100003712","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003712","name":"Korean Food Research Institute","doi-asserted-by":"crossref","award":["K14280"],"award-info":[{"award-number":["K14280"]}],"id":[{"id":"10.13039\/501100003712","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003718","name":"Korean Institute of Oriental Medicine","doi-asserted-by":"crossref","award":["K14281"],"award-info":[{"award-number":["K14281"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003718","name":"Korean Institute of Oriental Medicine","doi-asserted-by":"crossref","award":["K14280"],"award-info":[{"award-number":["K14280"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Blood stasis (BS) is characterized as a disorder of blood circulation. In traditional Korean medicine (TKM), it is viewed as a cause factor of diseases such as multiple sclerosis and stroke. This study investigated differences in the plasma metabolites profiles of subjects displaying BS or non-BS patterns. Thirty-one patients with cerebral infarction diagnosed with BS and an equal number of sex- and age-matched non-BS patients were enrolled. Metabolic profiling was performed using UPLC-MS. The ratio of subjects with a rough pulse and purple coloration of the tongue was higher in patients presenting with BS pattern. Through metabolomics analysis, 82 metabolites that differed significantly between the BS and non-BS pattern were identified, and the two groups were significantly separated using an orthogonal partial least square-discriminant analysis model<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. Of these 82 metabolites, acetyl carnitine, leucine, kynurenine, phosphocholine, hexanoyl carnitine, and decanoyl carnitine were present in significantly higher levels in patients with a BS pattern than those with a non-BS pattern. Our results also demonstrated that seven plasma metabolites, including acyl-carnitines and kynurenine, were associated with a BS pattern, suggesting that variant plasma metabolic profiles may serve as a biomarker for diagnosis of BS in patients with cerebral infarction.<\/jats:p>","DOI":"10.1155\/2015\/453423","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T16:02:11Z","timestamp":1425571331000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-6769","authenticated-orcid":true,"given":"Min Ho","family":"Cha","sequence":"first","affiliation":[{"name":"Medical Research Division, Korean Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of 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