{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:53:33Z","timestamp":1778907213930,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100009045","name":"Jagiellonian University Medical College","doi-asserted-by":"crossref","award":["K\/ZDS\/005802"],"award-info":[{"award-number":["K\/ZDS\/005802"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. We sought to investigate whether enhanced oxidation contributes to unfavorable fibrin clot properties in patients with diabetes.<jats:italic>Methods<\/jats:italic>. We assessed plasma fibrin clot permeation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>K<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>s<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>, a measure of the pore size in fibrin networks) and clot lysis time induced by recombinant tissue plasminogen activator (CLT) in 163 consecutive type 2 diabetic patients (92 men and 71 women) aged 65 \u00b1 8.8 years with a mean glycated hemoglobin (HbA1c) of 6.8%. We also measured oxidative stress markers, including nitrotyrosine, the soluble form of receptor for advanced glycation end products (sRAGE), 8-iso-prostaglandin F<jats:sub>2<jats:italic>\u03b1<\/jats:italic><\/jats:sub>(8-iso-PGF<jats:sub>2<jats:italic>\u03b1<\/jats:italic><\/jats:sub>), oxidized low-density lipoprotein (oxLDL), and advanced glycation end products (AGE).<jats:italic>Results<\/jats:italic>. There were inverse correlations between<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>K<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>s<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>and nitrotyrosine, sRAGE, 8-iso-PGF<jats:sub>2<jats:italic>\u03b1<\/jats:italic><\/jats:sub>, and oxLDL. CLT showed a positive correlation with oxLDL and nitrotyrosine but not with other oxidation markers. All these associations remained significant for<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mi>K<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>s<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>after adjustment for fibrinogen, disease duration, and HbA1c (all<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>), while oxLDL was the only independent predictor of CLT.<jats:italic>Conclusions<\/jats:italic>. Our study shows that enhanced oxidative stress adversely affects plasma fibrin clot properties in type 2 diabetic patients, regardless of disease duration and glycemia control.<\/jats:p>","DOI":"10.1155\/2015\/456189","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T21:02:42Z","timestamp":1439931762000},"page":"1-8","source":"Crossref","is-referenced-by-count":17,"title":["Increased Oxidation as an Additional Mechanism Underlying Reduced Clot Permeability and Impaired Fibrinolysis in Type 2 Diabetes"],"prefix":"10.1155","volume":"2015","author":[{"given":"Anna","family":"Lados-Krupa","sequence":"first","affiliation":[{"name":"Beskid Oncology Center, John Paul II Hospital, Bielsko-Biala, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Konieczynska","sequence":"additional","affiliation":[{"name":"Department for Diagnosis, John Paul II Hospital, Krakow, 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