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Recently, several studies suggest that galectin\u20109 (Gal\u20109) might play a pivotal role in the pathogenesis of autoimmune diseases. However, the exact role of Gal\u20109 in atherosclerosis remains to be elucidated. <jats:italic>Methods<\/jats:italic>. Serum Gal\u20109, high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), interferon\u2010 (IFN\u2010) <jats:italic>\u03b3<\/jats:italic>, interleukin\u2010 (IL\u2010) 4, IL\u201017, and transforming growth factor\u2010 (TGF\u2010) <jats:italic>\u03b2<\/jats:italic>1 were measured. The effect of Gal\u20109 on peripheral blood mononuclear cells (PBMC) was investigated in patients with normal coronary artery (NCA). <jats:italic>Results<\/jats:italic>. The lowest level of Gal\u20109 was found in the ST\u2010segment elevation myocardial infarction (STEMI) group, followed by the non\u2010ST\u2010segment elevation ACS (NSTEACS), the NCA, and the stable angina pectoris (SAP) groups, respectively. Additionally, Gal\u20109 was found to be independently associated with hs\u2010CRP, lipoprotein(a), and creatinine. Notably, Gal\u20109 was also noted to be an independent predictor of the Gensini score. Moreover, Gal\u20109 suppressed T\u2010helper 17 (Th17) and expanded regulatory T cells (Tregs), resulting in decreased IL\u201017 production and increased secretion of TGF\u2010<jats:italic>\u03b2<\/jats:italic>1. <jats:italic>Conclusions<\/jats:italic>. Serum Gal\u20109 is associated with not only coronary artery disease (CAD), but also the severity of coronary arteries stenosis. Gal\u20109 can expand Tregs and suppress Th17 development in activated PBMC, implying that Gal\u20109 has the potential to dampen the development of atherosclerosis and may be a new therapy for CAD.<\/jats:p>","DOI":"10.1155\/2015\/457167","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T21:03:24Z","timestamp":1447880604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Serum Galectin\u20109 Levels Are Associated with Coronary Artery Disease in Chinese 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