{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:08:55Z","timestamp":1777964935403,"version":"3.51.4"},"reference-count":45,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. Treatment of hepatorenal syndrome (HRS) in patients with liver cirrhosis is still challenging and characterized by a very high mortality. This study aimed to delineate treatment patterns and clinical outcomes of patients with HRS intravenously treated with terlipressin.<jats:italic>Methods<\/jats:italic>. In this retrospective single-center cohort study, 119 patients (median [IQR]; 56.50 [50.75\u201363.00] years of age) with HRS were included. All patients were treated with terlipressin and human albumin intravenously. Those with response to treatment (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>65<\/mml:mn><\/mml:math>) were compared to the patient cohort without improvement (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>54<\/mml:mn><\/mml:math>). Patient characteristics and clinical parameters (Child stage, ascites, hepatic encephalopathy, HRS type I\/II, and initial MELD score) were retrieved. Univariate analysis of factors influencing the success of terlipressin therapy and Cox regression analysis of factors influencing survival was carried out.<jats:italic>Results<\/jats:italic>. One-month survival was significantly longer in the group of responders (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.048<\/mml:mn><\/mml:math>). Cox regression analysis identified age [Hazard ratio, 95% confidence interval (CI); 1.05, 1.01\u20131.09, resp.], alcohol abuse [HR 3.05, 95% CI 1.11\u20138.38], duration of treatment [HR 0.92, 95% CI 0.88\u20130.96], and MELD score [HR 1.08, 95% CI 1.02\u20131.14] to be independent predictors of survival.<jats:italic>Conclusions<\/jats:italic>. Survival of HRS patients after treatment depends on age, etiology of liver disease, and the duration of treatment.<\/jats:p>","DOI":"10.1155\/2015\/457613","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T22:19:14Z","timestamp":1429827554000},"page":"1-8","source":"Crossref","is-referenced-by-count":22,"title":["Hepatorenal Syndrome: Outcome of Response to Therapy and Predictors of Survival"],"prefix":"10.1155","volume":"2015","author":[{"given":"Jan","family":"Heidemann","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Klinikum Bielefeld, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Bartels","sequence":"additional","affiliation":[{"name":"Department of Medicine B, University of M\u00fcnster, 48149 M\u00fcnster, 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