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The inflammatory activity of the anterior chamber was clinically scored, and leukocytes in the aqueous humor were quantified. RNA was extracted from the iris\/ciliary bodies and popliteal lymph nodes to reveal the dynamic changes of eight target miRNAs (miR\u2010155\u20105p, miR\u2010146a\u20105p, miR\u2010182\u20105p, miR\u2010183\u20105p, miR\u2010147b, miR\u201021\u20105p, miR\u20109\u20103p, and miR\u2010223\u20103p) and six cytokine mRNAs (IFN\u2010<jats:italic>\u03b3<\/jats:italic>, IL\u201017, IL\u201012A, IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, and IL\u201010). <jats:italic>In situ<\/jats:italic> hybridization of miRNA and enzyme\u2010linked immunosorbent assay quantification of cytokines were performed to confirm the results. <jats:italic>Results<\/jats:italic>. Disease activity and leukocyte quantification were maximum at day 15 after immunization. The profiling of miRNA revealed downregulation of miR\u2010146a\u20105p, miR\u2010155\u20105p, miR\u2010223\u20103p, and miR\u2010147b and upregulation of miR\u2010182\u20105p, miR\u2010183\u20105p, and miR\u20109\u20103p. Cytokine analysis revealed IFN\u2010<jats:italic>\u03b3<\/jats:italic>, IL\u201017, IL\u201012A, IL\u20101<jats:italic>\u03b2<\/jats:italic>, and IL\u20106 overexpression, with IL\u201010 downregulation. <jats:italic>Conclusions.<\/jats:italic> Dynamic changes of miRNAs were observed over the course of EAAU. By initiating NF\u2010<jats:italic>\u03ba<\/jats:italic>B signaling, the expressions of downstream cytokines and effector cells from the Th17 and Th1 lineages were sequentially activated, contributing to the disease.<\/jats:p>","DOI":"10.1155\/2015\/457835","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T21:02:25Z","timestamp":1449090145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Expression of MicroRNAs in the Eyes of Lewis Rats with Experimental Autoimmune Anterior 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