{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:08:20Z","timestamp":1788869300089,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/20214-7"],"award-info":[{"award-number":["2010\/20214-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    The aim of this study was to evaluate the gastroprotective activity of ethanolic extract of geopropolis (EEGP) from\n                    <jats:italic>Melipona scutellaris<\/jats:italic>\n                    and to investigate the possible mechanisms of action. The gastroprotective activity of the EEGP was evaluated using model ulcer induced by ethanol. To elucidate the possible mechanisms of action, we investigated the involvement of the nonprotein sulfhydryl (NP-SH) groups, nitric oxide and prostaglandins. In addition, the antisecretory activity of EEGP was also evaluated by pylorus ligated model. The EEGP orally administrated (300\u2009mg\/kg) reduced the ulcerative lesions induced by the ethanol (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    ). Regarding the mechanism of action, the prior administration of nitric oxide and prostaglandins antagonists suppressed the activity of gastroprotective EEGP (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    ). On the other hand the gastroprotective activity of EEGP was kept in the group pretreated with the antagonist of the NP-SH groups; furthermore the antisecretory activity was not significant (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&gt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    ). These results support the alternative medicine use of geopropolis as gastroprotective and the activities observed show to be related to nitric oxide and prostaglandins production.\n                  <\/jats:p>","DOI":"10.1155\/2015\/459846","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T03:01:33Z","timestamp":1428548493000},"page":"1-5","source":"Crossref","is-referenced-by-count":17,"title":["Gastroprotective Effect of Geopropolis from\n                    <i>Melipona scutellaris<\/i>\n                    Is Dependent on Production of Nitric Oxide and Prostaglandin"],"prefix":"10.1155","volume":"2015","author":[{"given":"Jer\u00f4nimo Aparecido","family":"Ribeiro-Junior","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, School of Dentistry of Piracicaba, University of Campinas, Avenue Limeira 901, 13414 903 Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Franchin","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, School of Dentistry of Piracicaba, University of Campinas, Avenue Limeira 901, 13414 903 Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Elias","family":"Cavallini","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, School of Dentistry of Piracicaba, University of Campinas, Avenue Limeira 901, 13414 903 Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Denny","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, School of Dentistry of Piracicaba, University of Campinas, Avenue Limeira 901, 13414 903 Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severino Matias de","family":"Alencar","sequence":"additional","affiliation":[{"name":"Department of Agro-Food Industry, Food and Nutrition, \u201cLuiz de Queiroz\u201d College of Agriculture, University of S\u00e3o Paulo, Avenue P\u00e1dua Dias 11, 13418-900 Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Ikegaki","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Rua Gabriel Monteiro da Silva 700, 37130-000 Alfenas, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Luiz","family":"Rosalen","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, School of Dentistry of Piracicaba, University of Campinas, Avenue Limeira 901, 13414 903 Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-010-0045-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.030"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1590\/S0100-879X2002000500003","volume":"35","year":"2002","journal-title":"Brazilian Journal of Medical and Biological 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