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We therefore conducted a pooled sample-based GWAS and distinguished histologically confirmed endometriosis subtypes. We performed an initial discovery step on 10-individual pools (two pools per condition). After quality control filtering, a Monte-Carlo simulation was used to rank the significant SNPs according to the ratio of allele frequencies and the coefficient of variation. Then, a replication step of individual genotyping was conducted in an independent cohort of 259 cases and 288 controls. Our approach was very stringent but probably missed a lot of information due to the Monte-Carlo simulation, which likely explained why we did not replicate results from \u201cclassic\u201d GWAS. Four variants (<jats:italic>rs227849<\/jats:italic>,<jats:italic>rs4703908<\/jats:italic>,<jats:italic>rs2479037<\/jats:italic>, and<jats:italic>rs966674<\/jats:italic>) were significantly associated with an increased risk of OMA.<jats:italic>Rs4703908<\/jats:italic>, located close to<jats:italic>ZNF366,<\/jats:italic>provided a higher risk of OMA (OR = 2.22; 95% CI: 1.26\u20133.92) and DIE, especially with bowel involvement (OR = 2.09; 95% CI: 1.12\u20133.91).<jats:italic>ZNF366<\/jats:italic>, involved in estrogen metabolism and progression of breast cancer, is a new biologically plausible candidate for endometriosis.<\/jats:p>","DOI":"10.1155\/2015\/461024","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T21:01:27Z","timestamp":1423083687000},"page":"1-8","source":"Crossref","is-referenced-by-count":29,"title":["Identification of Susceptibility Genes for Peritoneal, Ovarian, and Deep Infiltrating Endometriosis Using a Pooled Sample-Based 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