{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:59:26Z","timestamp":1790618366221,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The aim of this study was to evaluate crude extracts and fractions from leaves and stems of<jats:italic>Lippia thymoides<\/jats:italic>and to validate their use in folk medicine.<jats:italic>In vitro<\/jats:italic>antioxidant and antimicrobial activities and<jats:italic>in vivo<\/jats:italic>wound healing in rats, baker yeast-induced fever in young rats, and acute oral toxicity in mice assays were realized. The crude extracts and their dichloromethane and ethyl acetate fractions had potent radical-scavenging activity against the DPPH but were not effective in the<jats:italic>\u03b2<\/jats:italic>-carotene bleaching method. The dichloromethane fraction from the leaves extract showed the broadest spectrum of activity against<jats:italic>S. aureus<\/jats:italic>,<jats:italic>B. cereus<\/jats:italic>, and<jats:italic>C. parapsilosis<\/jats:italic>. The animals treated with crude extracts showed no difference in wound healing when compared with the negative control group. The crude extract from leaves (1200\u2009mg\/kg) has equal efficacy in reducing temperature in rats with hyperpyrexia compared to dipyrone (240\u2009mg\/kg) and is better than paracetamol (150\u2009mg\/kg). In acute toxicity test, crude extract of leaves from<jats:italic>Lippia thymoides<\/jats:italic>exhibited no mortality and behavioral changes and no adverse effects in male and female mice. This work validates the popular use of<jats:italic>Lippia thymoides<\/jats:italic>for treating the wound and fever, providing a source for biologically active substances.<\/jats:p>","DOI":"10.1155\/2015\/463248","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T21:01:31Z","timestamp":1427662891000},"page":"1-10","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacological Basis for Traditional Use of the<i>Lippia thymoides<\/i>"],"prefix":"10.1155","volume":"2015","author":[{"given":"Fabr\u00edcio Souza","family":"Silva","sequence":"first","affiliation":[{"name":"N\u00facleo de Estudos e Pesquisas em Plantas Medicinais, Colegiado de Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Vale do S\u00e3o Francisco, Avenida Jos\u00e9 de S\u00e1 Mani\u00e7oba, s\/n, Centro, 56304-917 Petrolina, PE, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade 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