{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:48:25Z","timestamp":1790819305104,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Littoral cell angioma is a rare vascular tumor of the spleen. The pathogenesis is unknown but the lesion is associated with several malignancies and immunological disorders. The diagnosis requires histopathological examination. The malignant potential of this lesion is unknown, which is why splenectomy is recommend for all cases. Symptomatic cases generally suffer from hypersplenism and pyrexia. A previously healthy 20-year-old female was diagnosed with colonic Crohn\u2019s disease; as part of the work-up a magnetic resonance enterography was performed which showed multiple signal changes of the spleen. The patient reported chronic abdominal pain in the left upper quadrant, malaise, and fever. The unknown splenic lesions prompted a laparoscopic splenectomy; pathology revealed a littoral cell angioma. The abdominal pain and malaise remitted but the fever persisted one year despite adequate treatment of the patient\u2019s Crohn\u2019s disease. Littoral cell angioma is associated with immune-dysregulation including Crohn\u2019s disease with several reported cases. Signs and symptoms of hypersplenism and splenic lesions on imaging should raise suspicion of littoral cell angioma in patients with Crohn\u2019s disease. Magnetic resonance enterography to assess disease severity in Crohn\u2019s disease may provide an opportunity to study the prevalence and natural history of this rare splenic tumor.<\/jats:p>","DOI":"10.1155\/2015\/474969","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T21:02:23Z","timestamp":1422565343000},"page":"1-4","source":"Crossref","is-referenced-by-count":5,"title":["Littoral Cell Angioma in a Patient with Crohn\u2019s Disease"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-9266","authenticated-orcid":true,"given":"Joel","family":"Johansson","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Department of Clinical and Experimental Medicine, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bergthor","family":"Bj\u00f6rnsson","sequence":"additional","affiliation":[{"name":"Department of Surgery, County Council of \u00d6sterg\u00f6tland, 58185 Link\u00f6ping, Sweden"},{"name":"Division of Surgery, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Link\u00f6ping University, 581 85 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ignatova","sequence":"additional","affiliation":[{"name":"Department of Pathology, Link\u00f6ping University Hospital, 581 85 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Sandstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Surgery, County Council of \u00d6sterg\u00f6tland, 58185 Link\u00f6ping, Sweden"},{"name":"Division of Surgery, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Link\u00f6ping University, 581 85 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Ekstedt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Department of Clinical and Experimental Medicine, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199111000-00001"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/030089169808400516","volume":"84","year":"1998","journal-title":"Tumori"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cursur.2006.06.011"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s002619900419"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-011-9697-x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1148\/rg.244045006"},{"issue":"2","key":"7","first-page":"222","volume":"9","year":"2005","journal-title":"Journal of the Society of Laparoendoscopic Surgeons"},{"issue":"2","key":"8","first-page":"63","volume":"7","year":"2014","journal-title":"Gastrointestinal Cancer Research"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.47102\/annals-acadmedsg.V33N4p524","volume":"33","year":"2004","journal-title":"Annals of the Academy of Medicine Singapore"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.204"},{"issue":"11","key":"11","volume":"88","year":"2003","journal-title":"Haematologica"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-9-106"}],"container-title":["Case Reports in Gastrointestinal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crigm\/2015\/474969.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crigm\/2015\/474969.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crigm\/2015\/474969.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T22:20:13Z","timestamp":1717712413000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crigm\/2015\/474969\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":12,"alternative-id":["474969","474969"],"URL":"https:\/\/doi.org\/10.1155\/2015\/474969","relation":{},"ISSN":["2090-6528","2090-6536"],"issn-type":[{"value":"2090-6528","type":"print"},{"value":"2090-6536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}