{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:42:38Z","timestamp":1790048558341,"version":"4.0.1"},"reference-count":52,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T00:00:00Z","timestamp":1434240000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research and Treatment"],"published-print":{"date-parts":[[2015,6,14]]},"abstract":"<jats:p>We describe the clinical and biological features of ten patients with a survival superior to ten years (long survival), out of 175 patients diagnosed with Adult T-cell Leukemia\/Lymphoma (ATL) in Martinique (1983\u20132013). There were 5 lymphoma and 5 chronic subtypes. Five of them (3 chronic, 2 lymphoma) had been treated with valproic acid (VA) for neurological disorders developed before or after ATL diagnosis, suggesting a beneficial role for VA as a histone deacetylase inhibitor (HDI) in ATL treatment. Total duration of uninterrupted VA treatment ranged from 8 to 37 years. Overall, the 175 incident ATL cases presented with a median survival of 5.43 months. The five VA-treated (VA<jats:sup>+<\/jats:sup>) patients presented with longer survival compared to VA treatment-free patients (VA<jats:sup>\u2212<\/jats:sup>). For chronic subtypes, survival periods were of 213 months for 3 VA<jats:sup>+<\/jats:sup> patients and of 33 months for 11 VA<jats:sup>\u2212<\/jats:sup> patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.023<\/mml:mn><\/mml:math>). For lymphoma subtypes, survival periods were of 144 months for 2 VA<jats:sup>+<\/jats:sup> patients versus 6 months for 49 VA<jats:sup>\u2212<\/jats:sup> patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0046<\/mml:mn><\/mml:math>). ATL cases with skin lesions, particularly lymphoma subtypes, had a longer survival (13.96 months) compared to those without skin lesions (6.06 months, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>). Eight out of the 10 patients presenting with long survival had skin lesions.<\/jats:p>","DOI":"10.1155\/2015\/476805","type":"journal-article","created":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T21:01:22Z","timestamp":1434315682000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics of Adult T-Cell Leukemia\/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid"],"prefix":"10.1155","volume":"2015","author":[{"given":"Plumelle","family":"Yves","sequence":"first","affiliation":[{"name":"Department of Biological Haematology\/Martinique Registry of Haematological Malignancies, Pierre-Zobda Quitman Hospital, University Hospital of Martinique, 97200 Fort-de-France, Martinique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Stephane","sequence":"additional","affiliation":[{"name":"Martinique Cancer Screening Center, 127 Route de Redoute, 97200 Fort-de-France, Martinique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banydeen","family":"Rishika","sequence":"additional","affiliation":[{"name":"Clinical Research and Innovation Unit, Pierre-Zobda Quitman Hospital, University Hospital of Martinique, 97200 Fort-de-France, Martinique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delaunay","family":"Christine","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mangot-Vulcin Hospital, University Hospital of Martinique, 97232 Lamentin, Martinique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panelatti","family":"G\u00e9rard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Pierre Zobda-Quitman Hospital, University Hospital of Martinique, 97200 Fort-de-France, 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