{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:01:07Z","timestamp":1762459267963},"reference-count":40,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Research Committee of the University of Thessaly, Thessaly, Greece"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The objective of this study was to assess the frequency of<jats:italic>MBL2<\/jats:italic>genotypes and their associations with MBL levels and various morbidities of a neonatal intensive care unit (NICU). One hundred and thirty-four (134) NICU (83 term and 51 preterm) and 150 healthy neonates were enrolled in the study.<jats:italic>MBL2<\/jats:italic>genotype and MBL serum levels at birth were determined prospectively by PCR-RFLP-sequencing and enzyme-linked immunosorbent assay, respectively. NICU neonates displayed significantly lower MBL serum levels compared to healthy ones. MBL deficiency, defined as the low<jats:italic>MBL2<\/jats:italic>expression group (XA\/O and O\/O), was significantly associated with an increased risk of respiratory morbidity, especially transient tachypnea of the newborn and respiratory distress syndrome (RDS). Moreover, an increase of 100\u2009ng\/mL of serum MBL levels decreases by 5% the risk of total respiratory morbidity and by 7% the risk of RDS, after correction for prematurity and sex and regardless of the presence of infections. Our study further supports the notion that neonates with MBL deficiency and low MBL serum levels at birth may be at higher risk of developing severe respiratory complications.<\/jats:p>","DOI":"10.1155\/2015\/478412","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T23:32:47Z","timestamp":1427239967000},"page":"1-10","source":"Crossref","is-referenced-by-count":18,"title":["<i>MBL2<\/i>Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates"],"prefix":"10.1155","volume":"2015","author":[{"given":"Matthaios","family":"Speletas","sequence":"first","affiliation":[{"name":"Department of Immunology & Histocompatibility, School of Health Sciences, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, Biopolis 3, 41500 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonios","family":"Gounaris","sequence":"additional","affiliation":[{"name":"Neonatal 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