{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:20:20Z","timestamp":1787984420083,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100002069","name":"Fraternal Order of Eagles","doi-asserted-by":"publisher","award":["R24 DK96518"],"award-info":[{"award-number":["R24 DK96518"]}],"id":[{"id":"10.13039\/100002069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002069","name":"Fraternal Order of Eagles","doi-asserted-by":"publisher","award":["R01 DK097820"],"award-info":[{"award-number":["R01 DK097820"]}],"id":[{"id":"10.13039\/100002069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002069","name":"Fraternal Order of Eagles","doi-asserted-by":"publisher","award":["R24 DK96518"],"award-info":[{"award-number":["R24 DK96518"]}],"id":[{"id":"10.13039\/100002069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002069","name":"Fraternal Order of Eagles","doi-asserted-by":"publisher","award":["R01 DK097820"],"award-info":[{"award-number":["R01 DK097820"]}],"id":[{"id":"10.13039\/100002069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Cardiac septal overgrowth complicates 10\u201340% of births from diabetic mothers, but perplexingly hyperglycemia markers during pregnancy are not reliably predictive. We thus tested whether fetal exposure to hyperglycemia is sufficient to induce fetal cardiac septal overgrowth even in the absence of systemic maternal diabetes. To isolate the effects of hyperglycemia, we infused glucose into the blood supply of the left but not right uterine horn in nondiabetic pregnant rats starting on gestational day 19. After 24\u2009h infusion, right-sided fetuses and dams remained euglycemic while left-sided fetuses were moderately hyperglycemic. Echocardiograms in utero demonstrated a thickened cardiac septum among left-sided (glucose-exposed, 0.592 \u00b1 0.016\u2009mm) compared to right-sided (control, 0.482 \u00b1 0.016\u2009mm) fetuses. Myocardial proliferation was increased 1.5 \u00b1 0.2-fold among left-sided compared to right-sided fetuses. Transcriptional markers of glucose-derived anabolism were not different between sides. However, left-sided fetuses exhibited higher serum insulin and greater JNK phosphorylation compared to controls. These results show that hyperglycemic exposure is sufficient to rapidly induce septal overgrowth even in the absence of the myriad other factors of maternal diabetes. This suggests that even transient spikes in glucose may incite cardiac overgrowth, perhaps explaining the poor clinical correlation of septal hypertrophy with chronic hyperglycemia.<\/jats:p>","DOI":"10.1155\/2015\/479565","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T17:22:19Z","timestamp":1431019339000},"page":"1-11","source":"Crossref","is-referenced-by-count":31,"title":["Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats"],"prefix":"10.1155","volume":"2015","author":[{"given":"Erin E.","family":"Gordon","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin E.","family":"Reinking","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, 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