{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:02:00Z","timestamp":1780578120617,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":154,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. The study characterizes the impact of obesity on postoperative radiation\u2010associated toxicities in women with endometrial cancer (EC). <jats:italic>Material and Methods<\/jats:italic>. A retrospective study identified 96 women with EC referred to a large urban institution\u2019s radiation oncology practice for postoperative whole pelvic radiotherapy (WPRT) and\/or intracavitary vaginal brachytherapy (ICBT). Demographic and clinicopathologic data were obtained. Toxicities were graded according to RTOG Acute Radiation Morbidity Scoring Criteria. Follow\u2010up period ranged from 1 month to 11 years (median 2 years). Data were analyzed by <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>, logistic regression, and recursive partitioning analyses. <jats:italic>Results<\/jats:italic>. 68 EC patients who received WPRT and\/or ICBT were analyzed. Median age was 52 years (29\u201373). The majority were Hispanic (71%). Median BMI at diagnosis was 34.5\u2009kg\/m<jats:sup>2<\/jats:sup> (20.5\u201356.6\u2009kg\/m<jats:sup>2<\/jats:sup>). BMI was independently associated with radiation\u2010related cutaneous (<jats:italic>p<\/jats:italic> = 0.022) and gynecologic\u2010related (<jats:italic>p<\/jats:italic> = 0.027) toxicities. Younger women also reported more gynecologic\u2010related toxicities (<jats:italic>p<\/jats:italic> = 0.039). Adjuvant radiation technique was associated with increased gastrointestinal\u2010 and genitourinary\u2010related toxicities but not gynecologic\u2010related toxicity. <jats:italic>Conclusions<\/jats:italic>. Increasing BMI was associated with increased frequency of gynecologic and cutaneous radiation\u2010associated toxicities. Additional studies to critically evaluate the radiation treatment dosing and treatment fields in obese EC patients are warranted to identify strategies to mitigate the radiation\u2010associated toxicities in these women.<\/jats:p>","DOI":"10.1155\/2015\/483208","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T21:04:07Z","timestamp":1433451847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Radiation\u2010Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?"],"prefix":"10.1155","volume":"2015","author":[{"given":"Savita 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