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A lean ZDF rat with the propensity for beta-cell failure was crossed with a polygenetically obese Crl:CD (SD) rat. Offspring were selectively inbred for obesity and diabetes for &gt;30 generations. In the current study, ZDSD rats were followed for 6 months; routine clinical metabolic endpoints were included throughout the study. In the prediabetic metabolic syndrome phase, ZDSD rats exhibited obesity with increased body fat, hyperglycemia, insulin resistance, dyslipidemia, glucose intolerance, and elevated HbA1c. As disease progressed to overt diabetes, ZDSD rats demonstrated elevated glucose levels, abnormal oral glucose tolerance, increases in HbA1c levels, reductions in body weight, increased insulin resistance with decreasing insulin levels, and dyslipidemia. The ZDSD rat develops prediabetic metabolic syndrome and T2D in a manner that mirrors the development of metabolic syndrome and T2D in humans. ZDSD rats will provide a novel, translational animal model for the study of human metabolic diseases and for the development of new therapies.<\/jats:p>","DOI":"10.1155\/2015\/487816","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:09:14Z","timestamp":1429229354000},"page":"1-10","source":"Crossref","is-referenced-by-count":49,"title":["Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes"],"prefix":"10.1155","volume":"2015","author":[{"given":"Richard G.","family":"Peterson","sequence":"first","affiliation":[{"name":"PreClinOmics, Inc., 7918 Zionsville Road, Indianapolis, IN 46268, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles V.","family":"Jackson","sequence":"additional","affiliation":[{"name":"PreClinOmics, Inc., 7918 Zionsville Road, Indianapolis, IN 46268, 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