{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:37:56Z","timestamp":1777865876749,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81101835"],"award-info":[{"award-number":["81101835"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2013RCA021"],"award-info":[{"award-number":["2013RCA021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2014CB744505"],"award-info":[{"award-number":["2014CB744505"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["188310+710211\/058\/001"],"award-info":[{"award-number":["188310+710211\/058\/001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Y560252013"],"award-info":[{"award-number":["Y560252013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Y2110299"],"award-info":[{"award-number":["Y2110299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Bureau of Zhejiang Province","award":["81101835"],"award-info":[{"award-number":["81101835"]}]},{"name":"Health Bureau of Zhejiang Province","award":["2013RCA021"],"award-info":[{"award-number":["2013RCA021"]}]},{"name":"Health Bureau of Zhejiang Province","award":["2014CB744505"],"award-info":[{"award-number":["2014CB744505"]}]},{"name":"Health Bureau of Zhejiang Province","award":["188310+710211\/058\/001"],"award-info":[{"award-number":["188310+710211\/058\/001"]}]},{"name":"Health Bureau of Zhejiang Province","award":["Y560252013"],"award-info":[{"award-number":["Y560252013"]}]},{"name":"Health Bureau of Zhejiang Province","award":["Y2110299"],"award-info":[{"award-number":["Y2110299"]}]},{"name":"National Key Basic Research Program of China","award":["81101835"],"award-info":[{"award-number":["81101835"]}]},{"name":"National Key Basic Research Program of China","award":["2013RCA021"],"award-info":[{"award-number":["2013RCA021"]}]},{"name":"National Key Basic Research Program of China","award":["2014CB744505"],"award-info":[{"award-number":["2014CB744505"]}]},{"name":"National Key Basic Research Program of China","award":["188310+710211\/058\/001"],"award-info":[{"award-number":["188310+710211\/058\/001"]}]},{"name":"National Key Basic Research Program of China","award":["Y560252013"],"award-info":[{"award-number":["Y560252013"]}]},{"name":"National Key Basic Research Program of China","award":["Y2110299"],"award-info":[{"award-number":["Y2110299"]}]},{"name":"Zhejiang Provincial Key Discipline Construction of Medical Imaging and Nuclear Medicin","award":["81101835"],"award-info":[{"award-number":["81101835"]}]},{"name":"Zhejiang Provincial Key Discipline Construction of Medical Imaging and Nuclear Medicin","award":["2013RCA021"],"award-info":[{"award-number":["2013RCA021"]}]},{"name":"Zhejiang Provincial Key Discipline Construction of Medical Imaging and Nuclear Medicin","award":["2014CB744505"],"award-info":[{"award-number":["2014CB744505"]}]},{"name":"Zhejiang Provincial Key Discipline Construction of Medical Imaging and Nuclear Medicin","award":["188310+710211\/058\/001"],"award-info":[{"award-number":["188310+710211\/058\/001"]}]},{"name":"Zhejiang Provincial Key Discipline Construction of Medical Imaging and Nuclear Medicin","award":["Y560252013"],"award-info":[{"award-number":["Y560252013"]}]},{"name":"Zhejiang Provincial Key Discipline Construction of Medical Imaging and Nuclear Medicin","award":["Y2110299"],"award-info":[{"award-number":["Y2110299"]}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["81101835"],"award-info":[{"award-number":["81101835"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["2013RCA021"],"award-info":[{"award-number":["2013RCA021"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["2014CB744505"],"award-info":[{"award-number":["2014CB744505"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["188310+710211\/058\/001"],"award-info":[{"award-number":["188310+710211\/058\/001"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["Y560252013"],"award-info":[{"award-number":["Y560252013"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["Y2110299"],"award-info":[{"award-number":["Y2110299"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science Foundation of Zhejiang Province","award":["81101835"],"award-info":[{"award-number":["81101835"]}]},{"name":"Science Foundation of Zhejiang Province","award":["2013RCA021"],"award-info":[{"award-number":["2013RCA021"]}]},{"name":"Science Foundation of Zhejiang Province","award":["2014CB744505"],"award-info":[{"award-number":["2014CB744505"]}]},{"name":"Science Foundation of Zhejiang Province","award":["188310+710211\/058\/001"],"award-info":[{"award-number":["188310+710211\/058\/001"]}]},{"name":"Science Foundation of Zhejiang Province","award":["Y560252013"],"award-info":[{"award-number":["Y560252013"]}]},{"name":"Science Foundation of Zhejiang Province","award":["Y2110299"],"award-info":[{"award-number":["Y2110299"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. After initial treatment of breast cancer (BC), monitoring locoregional recurrence and distant metastases is a great clinical challenge.<jats:italic>Objective<\/jats:italic>. To evaluate the efficacy of PET\/CT in association with serum tumor makers in BC follow-up.<jats:italic>Methods<\/jats:italic>. Twenty-six women with a history of modified radical mastectomy were evaluated by<jats:sup>18<\/jats:sup>F-FDG PET\/CT. The results of PET\/CT were compared with those of conventional imaging techniques (CITs) (including mammography, chest radiography, CT, MRI, ultrasound, and bone scintigraphy). Serum tumor markers of CEA, CA 125, and CA 15-3 in the BC patients were also analyzed in association with the results of PET\/CT.<jats:italic>Results<\/jats:italic>. Compared with CITs, PET\/CT was more sensitive to detect the malignant foci and had better patient-based sensitivity and specificity. The mean CA 15-3 serum level was significantly higher in the confirmed positive patients of PET\/CT results than in the confirmed negative ones, while there were no significant differences in the serum levels of CEA and CA 125 of both groups.<jats:italic>Conclusion<\/jats:italic>. PET\/CT is a highly efficient tool for BC follow-up compared with CITs. The high serum levels of CA 15-3 in confirmed positive PET\/CT patients indicated the clinical value of CA 15-3 in BC follow-up.<\/jats:p>","DOI":"10.1155\/2015\/489021","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T23:32:26Z","timestamp":1427239946000},"page":"1-5","source":"Crossref","is-referenced-by-count":16,"title":["The Diagnostic Value of<sup><b>18<\/b><\/sup>F-FDG PET\/CT in Association with Serum Tumor Marker Assays in Breast Cancer Recurrence and Metastasis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Ying","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Oncology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"Zhejiang University Medical PET Center, Hangzhou 310009, China"},{"name":"Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China"},{"name":"Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing 307 Hospital, Beijing 100071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2201-2523","authenticated-orcid":true,"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"Zhejiang University Medical PET Center, Hangzhou 310009, China"},{"name":"Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China"},{"name":"Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"Zhejiang University Medical PET Center, Hangzhou 310009, China"},{"name":"Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China"},{"name":"Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2920-6702","authenticated-orcid":true,"given":"Said","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, Kafr El Sheikh University, Kafr El Sheikh 33516, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"Zhejiang University Medical PET Center, Hangzhou 310009, China"},{"name":"Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China"},{"name":"Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.14.1143"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.3.r99se41829"},{"issue":"3","key":"4","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1200\/JCO.1999.17.3.1080","volume":"17","year":"1999","journal-title":"Journal of Clinical Oncology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303645"},{"issue":"1","key":"6","volume":"25","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1177\/153303460400300602","volume":"3","year":"2004","journal-title":"Technology in Cancer Research and Treatment"},{"issue":"4","key":"8","first-page":"505","volume":"12","year":"2007","journal-title":"Journal of BUON"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0746-6"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-004-3291-7"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25727"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02984567"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00429-4"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1174"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)00356-A"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr154"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/01.rct.0000284394.83696.42"},{"issue":"1","key":"18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1470-7330-14-1","volume":"14","year":"2014","journal-title":"Cancer Imaging"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2009.11.009"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0880-8"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22292"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1835-7"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.059832"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/489021.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/489021.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/489021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T04:28:42Z","timestamp":1598848122000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/489021\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":23,"alternative-id":["489021","489021"],"URL":"https:\/\/doi.org\/10.1155\/2015\/489021","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}