{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:10:39Z","timestamp":1759032639846},"reference-count":61,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The thalamocortical dysrhythmia (TCD) model has been influential in the development of theoretical explanations for the neurological mechanisms of tinnitus. It asserts that thalamocortical oscillations lock a region in the auditory cortex into an ectopic slow-wave theta rhythm (4\u20138\u2009Hz). The cortical area surrounding this region is hypothesized to generate abnormal gamma (&gt;30\u2009Hz) oscillations (\u201cedge effect\u201d) giving rise to the tinnitus percept. Consequently, the model predicts enhanced cross-frequency coherence in a broad range between theta and gamma. In this magnetoencephalography study involving tinnitus and control cohorts, we investigated this prediction. Using beamforming, cross-frequency amplitude-amplitude coupling (AAC) was computed within the auditory cortices for frequencies (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msub><mml:mrow><mml:mi>f<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">1<\/mml:mn><\/mml:mrow><\/mml:msub><mml:mo>,<\/mml:mo><mml:msub><mml:mrow><mml:mi>f<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:math>) between 2 and 80\u2009Hz. We find the AAC signal to decompose into two distinct components at low (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:msub><mml:mrow><mml:mi>f<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">1<\/mml:mn><\/mml:mrow><\/mml:msub><mml:mo>,<\/mml:mo><mml:msub><mml:mrow><mml:mi>f<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:mrow><\/mml:msub><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">30<\/mml:mn><\/mml:math>\u2009Hz) and high (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:msub><mml:mrow><mml:mi>f<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">1<\/mml:mn><\/mml:mrow><\/mml:msub><mml:mo>,<\/mml:mo><mml:msub><mml:mrow><mml:mi>f<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:mrow><\/mml:msub><mml:mo>&gt;<\/mml:mo><mml:mn fontstyle=\"italic\">30<\/mml:mn><\/mml:math>\u2009Hz) frequencies, respectively. Studying the correlation of AAC with several key covariates (age, hearing level (HL), tinnitus handicap and duration, and HL at tinnitus frequency), we observe a statistically significant association between age and low-frequency AAC. Contrary to the TCD predictions, however, we do not find any indication of statistical differences in AAC between tinnitus and controls and thus no evidence for the predicted enhancement of cross-frequency coupling in tinnitus.<\/jats:p>","DOI":"10.1155\/2015\/489619","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T21:03:41Z","timestamp":1447967021000},"page":"1-15","source":"Crossref","is-referenced-by-count":8,"title":["Source-Space Cross-Frequency Amplitude-Amplitude Coupling in Tinnitus"],"prefix":"10.1155","volume":"2015","author":[{"given":"Oliver","family":"Zobay","sequence":"first","affiliation":[{"name":"MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyman","family":"Adjamian","sequence":"additional","affiliation":[{"name":"MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, 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