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Comparison of murine models with different inflammatory responses for ALD is important for an evaluation of the importance of genetic background in the interpretation of ethanol\u2010induced phenotypes. Here, we investigated the role of inflammation and genetic background for the establishment of ALD using two different mouse strains: C57BL\/6 (B6) and A\/J. B6 and A\/J mice were treated with a high fat diet containing ethanol (HFDE) and compared to the controls for 10 weeks. Hepatomegaly and steatohepatitis were similar in B6 and A\/J mice, but only A\/J mice were resistant to weight gain. On the other hand, HFDE\u2010fed B6 accumulated more triglycerides (TG) and cholesterol and presented more intense cellular infiltrate in the liver when compared to HFDM\u2010fed mice. Liver inflammatory environment was distinct in these two mouse strains. While HFDE\u2010fed B6 produced more liver IL\u201012, A\/J mice increased the TNF\u2010<jats:italic>\u03b1<\/jats:italic> production. We concluded that mouse genetic background could dictate the intensity of the HFDE\u2010induced liver injury.<\/jats:p>","DOI":"10.1155\/2015\/491641","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T06:18:14Z","timestamp":1442211494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["C57BL\/6 and A\/J Mice Have Different Inflammatory Response and Liver Lipid Profile in Experimental Alcoholic Liver Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"Lorena","family":"Bavia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cdris Arantes 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