{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:10:46Z","timestamp":1781583046133,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273666"],"award-info":[{"award-number":["81273666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["wztn201309"],"award-info":[{"award-number":["wztn201309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JA12166"],"award-info":[{"award-number":["JA12166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Traditional Chinese Medicine Scientific Research of Fujian Province","award":["81273666"],"award-info":[{"award-number":["81273666"]}]},{"name":"Traditional Chinese Medicine Scientific Research of Fujian Province","award":["wztn201309"],"award-info":[{"award-number":["wztn201309"]}]},{"name":"Traditional Chinese Medicine Scientific Research of Fujian Province","award":["JA12166"],"award-info":[{"award-number":["JA12166"]}]},{"name":"Key Project of Fujian Education Department","award":["81273666"],"award-info":[{"award-number":["81273666"]}]},{"name":"Key Project of Fujian Education Department","award":["wztn201309"],"award-info":[{"award-number":["wztn201309"]}]},{"name":"Key Project of Fujian Education Department","award":["JA12166"],"award-info":[{"award-number":["JA12166"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Erchen decoction (ECD) is a traditional Chinese medicine prescription, which is used in the treatment of obesity, hyperlipidemia, fatty liver, diabetes, hypertension, and other diseases caused by retention of phlegm dampness. In this study we investigated the potential mechanism of ECD, using metabolism-disabled mice induced by high-fat diet. Body weight and abdominal circumference were detected. OGTT was measured by means of collecting blood samples from the tail vein. Blood lipid levels and insulin were measured using biochemical assay kit. Real-time PCR was used to measure the CDKAL1 gene expression and western blot was used to measure the protein expression. Through the research, it was found that ECD showed markedly lower body weight and abdominal circumference than those in the HFD group. Consistently, we observed that ECD significantly improved glucose tolerance, promoted the secretion of insulin and decreased the level of TG, TC level. Meanwhile, we observed significantly increased CDKAL1 mRNA and protein level in the ECD group. Therefore, we speculate that the potential molecular mechanism of ECD is to promote the CDKAL1 expression, ameliorate islet cell function, and raise insulin levels to regulate the metabolic disorder.<\/jats:p>","DOI":"10.1155\/2015\/501272","type":"journal-article","created":{"date-parts":[[2015,10,4]],"date-time":"2015-10-04T17:05:26Z","timestamp":1443978326000},"page":"1-9","source":"Crossref","is-referenced-by-count":18,"title":["Erchen Decoction Prevents High-Fat Diet Induced Metabolic Disorders in C57BL\/6 Mice"],"prefix":"10.1155","volume":"2015","author":[{"given":"Bi-Zhen","family":"Gao","sequence":"first","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine, Fujian 350122, China"},{"name":"Fujian Key Laboratory of TCM Health State, Fujian University of Traditional Chinese Medicine, Fujian 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Quanzhou City Hospital of Traditional Chinese Medicine, Fujian 362002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Hong","family":"Liao","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine, Fujian 350122, China"},{"name":"Fujian Key Laboratory of TCM Health State, Fujian University of Traditional Chinese Medicine, Fujian 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Xu","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine, Fujian 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine, Fujian 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Shan","family":"Ding","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine, Fujian 350122, China"},{"name":"Fujian Key Laboratory of TCM Health State, Fujian University of Traditional Chinese Medicine, Fujian 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"9","key":"1","first-page":"2802","volume":"28","year":"2013","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"issue":"19","key":"2","first-page":"1","volume":"6","year":"2014","journal-title":"Clinical Journal of Chinese Medicine"},{"issue":"5","key":"3","first-page":"287","volume":"11","year":"2013","journal-title":"Guide of China Medicine"},{"issue":"5","key":"4","first-page":"128","volume":"28","year":"2014","journal-title":"Journal of Practical Traditional Chinese Internal Medicine"},{"issue":"5","key":"5","first-page":"763","volume":"25","year":"2010","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"issue":"11","key":"6","first-page":"1858","volume":"25","year":"2010","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"issue":"4","key":"7","first-page":"13","volume":"7","year":"2010","journal-title":"Journal of Yangtze University (Natural Science Edition) Medicine V"},{"issue":"5, article 343","key":"8","volume":"46","year":"2011","journal-title":"Zhejiang Journal of Traditional Chinese Medicine"},{"issue":"15","key":"9","first-page":"22","volume":"11","year":"2014","journal-title":"Medical Innovation of China"},{"issue":"4","key":"10","first-page":"44","volume":"25","year":"2015","journal-title":"Chinese Journal of Comparative Medicine"},{"issue":"6","key":"11","first-page":"1243","volume":"31","year":"2013","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.106831"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1172\/jci58056"},{"key":"14","year":"2006"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"issue":"7","key":"16","first-page":"470","volume":"4","year":"2009","journal-title":"World Journal of Integrated Traditional and Western Medicine"},{"issue":"9","key":"17","first-page":"1833","volume":"29","year":"1833","journal-title":"Guangming Journal of Chinese Medicine"},{"issue":"9","key":"18","first-page":"2060","volume":"25","year":"2014","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"issue":"8","key":"19","first-page":"594","volume":"31","year":"2012","journal-title":"Shandong Journal of Traditional Chinese Medicine"},{"issue":"5","key":"20","first-page":"713","volume":"30","year":"2013","journal-title":"Journal of Guangzhou University of Traditional Chinese Medicine"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201000048"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.034"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ11-0099"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0949"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015553"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0736"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049055"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.6"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.08.075"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.151256"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2015.05.001"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i2.358"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1083-z"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0117"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-008-0080-5"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12315"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/501272.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/501272.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/501272.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T18:26:44Z","timestamp":1469644004000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2015\/501272\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":36,"alternative-id":["501272","501272"],"URL":"https:\/\/doi.org\/10.1155\/2015\/501272","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}