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In this work, a simple and highly sensitive electrochemical sensor for the determination of 8-OHdG was fabricated incorporating single wall carbon nanotubes- (SWCNTs-) Nafion composite film coated on glassy carbon electrode. Nafion was chosen as an optimal adhesive agent from a series of adhesive agents and acted as a binder, enrichment, and exclusion film. Due to the strong cation-exchange ability of Nafion and the outstanding electronic properties of SWCNTs, the prepared SWCNTs-Nafion film can strongly enhance the electrochemical response to oxidation of 8-OHdG and efficiently alleviate the interferences from uric acid and ascorbic acid. The oxidation peak currents are linear with the concentration of 8-OHdG in the range of 0.03 to 1.25\u2009<jats:italic>\u03bc<\/jats:italic>M with a detection limit of 8.0\u2009nM (S\/N = 3). This work demonstrates that SWCNTs-Nafion film can improve the sensitivity, selectivity, reproducibility, and stability, making it an ideal candidate for electrochemical detection of 8-OHdG.<\/jats:p>","DOI":"10.1155\/2015\/504869","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T02:18:14Z","timestamp":1442197094000},"page":"1-11","source":"Crossref","is-referenced-by-count":18,"title":["Highly Sensitive Electrochemical Sensor for the Determination of 8-Hydroxy-2\u2032-deoxyguanosine Incorporating SWCNTs-Nafion Composite Film"],"prefix":"10.1155","volume":"2015","author":[{"given":"Lingfei","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi\u2019an 710062, China"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Analytical Chemistry for 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