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However recent insights in the proteomics of diverse tissular cells have revealed that under stressful conditions they have a significant potential to initiate, coordinate, and perpetuate autoimmune processes, in many cases, ruling over the adaptive immune response cells; this ruling potential can also be confirmed by observations in several genetically manipulated animal models. Here, we review the pathogenesis of rheumatic diseases such as systemic lupus erythematous, rheumatoid arthritis, spondyloarthritis including ankylosing spondylitis, psoriasis, and Crohn\u2019s disease and provide realistic approaches based on the logic of the danger model. We assume that tissular dysfunction is a prerequisite for chronic autoimmunity and propose two genetically conferred hypothetical roles for the tissular cells causing the disease: (A) the Impaired cell and (B) the paranoid cell. Both roles are not mutually exclusive. Some examples in human disease and in animal models are provided based on current evidence.<\/jats:p>","DOI":"10.1155\/2015\/506089","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T21:03:39Z","timestamp":1429563819000},"page":"1-23","source":"Crossref","is-referenced-by-count":14,"title":["The Danger Model Approach to the Pathogenesis of the Rheumatic Diseases"],"prefix":"10.1155","volume":"2015","author":[{"given":"C\u00e9sar","family":"Pacheco-Tena","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de Chihuahua, Circuito No. 1, Nuevo Campus Universitario, 31240 Chihuahua, CHIH, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana Aide\u00e9","family":"Gonz\u00e1lez-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de Chihuahua, Circuito No. 1, Nuevo Campus Universitario, 31240 Chihuahua, CHIH, 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