{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:44:04Z","timestamp":1791215044194,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272860"],"award-info":[{"award-number":["81272860"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472443"],"award-info":[{"award-number":["81472443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202036"],"award-info":[{"award-number":["81202036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272860"],"award-info":[{"award-number":["81272860"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472443"],"award-info":[{"award-number":["81472443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202036"],"award-info":[{"award-number":["81202036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272860"],"award-info":[{"award-number":["81272860"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472443"],"award-info":[{"award-number":["81472443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202036"],"award-info":[{"award-number":["81202036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN).\n                    <jats:italic>Methods<\/jats:italic>\n                    . sNRP-1 was measured in 64 preoperative patients and 20 controls. NRP-1 protein in cervical tissue was detected in 56 patients and 20 controls.\n                    <jats:italic>Results<\/jats:italic>\n                    . Both sNRP-1 and NRP-1 proteins were correlated with stage. sNRP-1 presented a high diagnostic ability of cervical cancer and CIN, with a sensitivity of 70.97% and a specificity of 73.68%.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . sNRP-1 in circulating can serve as a possible valuable diagnostic biomarker for cervical cancer and CIN.\n                  <\/jats:p>","DOI":"10.1155\/2015\/506428","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T21:22:28Z","timestamp":1426800148000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker"],"prefix":"10.1155","volume":"2015","author":[{"given":"Shouhua","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Departments of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henghui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaiju","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglu","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"issue":"6","key":"22","first-page":"845","volume":"121","year":"1975","journal-title":"American Journal of Obstetrics & Gynecology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(96)70384-8"},{"issue":"1","key":"17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","volume":"13","year":"1999","journal-title":"The FASEB Journal"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0563"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m110.190801"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/35025220"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-669"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1042\/bj20071639"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2598"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132330"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20001115)88:460;584::aid-ijc1162;3.0.co;2-t"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/mpa.0000000000000117"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-1806-3"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.803"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-155"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/path.2989"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-013-1141-y"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404384"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28135"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-1942-9"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.1.4.8885"},{"key":"18","first-page":"105","volume":"29","year":"2006","journal-title":"International Journal of Oncology"},{"key":"1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155414538821"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/nature12428"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2014.977784"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.11.007"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2015\/506428.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2015\/506428.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2015\/506428.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T01:00:18Z","timestamp":1566435618000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/dm\/2015\/506428\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":27,"alternative-id":["506428","506428"],"URL":"https:\/\/doi.org\/10.1155\/2015\/506428","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}