{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:25:28Z","timestamp":1760646328803,"version":"3.37.3"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. We sought to determine the association between levels of adiponectin and oxidized low-density lipoprotein (ox-LDL) in patients with diabetic nephropathy as well as their effect on carotid intima-media thickness (cIMT).<jats:italic>Methods<\/jats:italic>. Adiponectin and ox-LDL were determined in 25 diabetic patients without nephropathy and 94 patients at different stages of diabetic nephropathy including subjects on hemodialysis. cIMT was measured using real-time B-mode ultrasonography.<jats:italic>Results<\/jats:italic>. Plasma adiponectin levels increased significantly with severity of diabetic nephropathy (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>), on the contrary to ox-LDL which decreased with disease severity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). cIMT was significantly higher at late stages of diabetic nephropathy compared with early stages (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.022<\/mml:mn><\/mml:math>). Adiponectin was a significant negative predictor of ox-LDL levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>\u03b2<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>-<\/mml:mo><mml:mn>5.45<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.023<\/mml:mn><\/mml:math>), independently of confounding factors. There was no significant correlation between cIMT and adiponectin or ox-LDL either in the total sample population or according to disease staging. Cluster analysis showed that patients with the highest cIMT values, highest levels of adiponectin, and lowest levels of ox-LDL were included in one cluster and all assigned to stage 5 of diabetic nephropathy.<jats:italic>Conclusions<\/jats:italic>. There was no significant association between adiponectin or ox-LDL and cIMT and, therefore, other factors affecting this surrogate marker of cardiovascular disease in diabetic nephropathy should be sought.<\/jats:p>","DOI":"10.1155\/2015\/507265","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T21:06:06Z","timestamp":1431464766000},"page":"1-8","source":"Crossref","is-referenced-by-count":20,"title":["Association of Plasma Adiponectin and Oxidized Low-Density Lipoprotein with Carotid Intima-Media Thickness in Diabetic Nephropathy"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7995-0177","authenticated-orcid":true,"given":"Anna","family":"Tavridou","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Georgoulidou","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Roumeliotis","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanos","family":"Roumeliotis","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstathia","family":"Giannakopoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Papanas","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Diabetes Clinic, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ploumis","family":"Passadakis","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vangelis G.","family":"Manolopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilis","family":"Vargemezis","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199401063300103"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2013.01.001"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1042\/cs20120198"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1172\/jci32691"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm828"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2010.01.021"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1177\/147323000703500413"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2007.02.014"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.201"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-13-0578"},{"issue":"1","key":"11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.beem.2013.08.002","volume":"28","year":"2014","journal-title":"Best Practice and Research: Clinical Endocrinology and Metabolism"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002319"},{"issue":"4","key":"13","first-page":"45","volume":"26","year":"2000","journal-title":"Diabetes & Metabolism"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0057"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00761.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(02)00134-1"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2012.00687.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.01.017"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.01.018"},{"issue":"1","key":"20","first-page":"77","volume":"23","year":"2010","journal-title":"Journal of Nephrology"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.05.051"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1159\/000330178"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1159\/000313033"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1159\/000094403"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1159\/000085707"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.10.022"},{"year":"2004","key":"27"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00925.x"},{"key":"29","first-page":"S1","volume":"39","year":"2002","journal-title":"American Journal of Kidney Diseases"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.12.002"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.1163"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"issue":"2","key":"33","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/clinchem\/38.2.182","volume":"38","year":"1992","journal-title":"Clinical Chemistry"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2010.10.019"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.02.032"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K06-016"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.5301\/jn.5000269"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.080351"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-2361"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1159\/000079921"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1177\/107602960300900304"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0774-9"},{"issue":"4","key":"43","first-page":"331","volume":"41","year":"2011","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2012.00683.x"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20097"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1530\/eje-06-0681"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0204"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.12.007"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2015\/507265.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2015\/507265.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2015\/507265.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T23:59:50Z","timestamp":1651967990000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jdr\/2015\/507265\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":48,"alternative-id":["507265","507265"],"URL":"https:\/\/doi.org\/10.1155\/2015\/507265","relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"type":"print","value":"2314-6745"},{"type":"electronic","value":"2314-6753"}],"subject":[],"published":{"date-parts":[[2015]]}}}