{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:35:57Z","timestamp":1791178557997,"version":"4.1.0"},"reference-count":34,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Center for Social Disease Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Chlamydia trachomatis<\/jats:italic>, the most common cause of sexually transmitted bacterial infection worldwide, has a unique biphasic developmental cycle alternating between the infectious elementary body and the replicative reticulate body.<jats:italic>C. trachomatis<\/jats:italic>is responsible for severe reproductive complications including pelvic inflammatory disease, ectopic pregnancy, and obstructive infertility. The aim of our study was to evaluate whether<jats:italic>Mentha suaveolens<\/jats:italic>essential oil (EOMS) can be considered as a promising candidate for preventing<jats:italic>C. trachomatis<\/jats:italic>infection. Specifically, we investigated the<jats:italic>in vitro<\/jats:italic>effects of EOMS towards<jats:italic>C. trachomatis<\/jats:italic>analysing the different phases of chlamydial developmental cycle. Our results demonstrated that EOMS was effective towards<jats:italic>C. trachomatis<\/jats:italic>, whereby it not only inactivated infectious elementary bodies but also inhibited chlamydial replication. Our study also revealed the effectiveness of EOMS, in combination with erythromycin, towards<jats:italic>C. trachomatis<\/jats:italic>with a substantial reduction in the minimum effect dose of antibiotic. In conclusion, EOMS treatment may represent a preventative strategy since it may reduce<jats:italic>C. trachomatis<\/jats:italic>transmission in the population and, thereby, reduce the number of new chlamydial infections and risk of developing of severe sequelae.<\/jats:p>","DOI":"10.1155\/2015\/508071","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T21:01:14Z","timestamp":1421960474000},"page":"1-7","source":"Crossref","is-referenced-by-count":22,"title":["Effects of<i>Mentha suaveolens<\/i>Essential Oil on<i>Chlamydia trachomatis<\/i>"],"prefix":"10.1155","volume":"2015","author":[{"given":"Rosa","family":"Sessa","sequence":"first","affiliation":[{"name":"Department of Public Health and Infectious Diseases, \u201cSapienza\u201d University, Piazzale Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Di Pietro","sequence":"additional","affiliation":[{"name":"Department of Public Health 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