{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:27:58Z","timestamp":1756312078951},"reference-count":15,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Hepatocellular carcinoma (HCC) generally occurs on the background of chronic liver disease. Chronic hepatitides B and C and alcoholic liver disease are well-known risk factors for HCC, and it is uncommon in noncirrhotic liver. Extrahepatic metastasis seldom occurs in patients with early stage intrahepatic HCC and isolated bone metastases as a first documented extrahepatic metastasis is unusual presentation. In this report, we present a rare case of small solitary HCC (&lt;3\u2009cm) in noncirrhotic liver, presenting isolated bone metastases as a sole manifestation in patient with no well-known risk factors. This case suggests that HCC should be considered as one of differential diagnoses in patient presenting with multiple bone metastases, even in the absence of liver cirrhosis.<\/jats:p>","DOI":"10.1155\/2015\/512849","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T21:02:49Z","timestamp":1447102969000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic Liver"],"prefix":"10.1155","volume":"2015","author":[{"given":"Soo Ya","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Ho","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Kwan","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong Seok","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"4","key":"1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0733-8619(18)30251-2","volume":"9","year":"1991","journal-title":"Neurologic Clinics"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199111000-00001"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3928\/0147-7447-19920501-10","volume":"15","year":"1992","journal-title":"Orthopedics"},{"key":"4","year":"2012"},{"issue":"1","key":"5","first-page":"45","volume":"45","year":"2005","journal-title":"The Korean Journal of Gastroenterology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01864.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.216.3.r00se24698"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-008-0410-6"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-006-1071-3"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199812150-00019"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/bf00271312"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2147\/BTT.S23907"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34168"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/106247"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.10.027"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2015\/512849.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2015\/512849.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2015\/512849.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T18:29:43Z","timestamp":1653503383000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crionm\/2015\/512849\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":15,"alternative-id":["512849","512849"],"URL":"https:\/\/doi.org\/10.1155\/2015\/512849","relation":{},"ISSN":["2090-6706","2090-6714"],"issn-type":[{"value":"2090-6706","type":"print"},{"value":"2090-6714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}